Results 61 to 70 of about 42,248,976 (243)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Uncovering the Galloway Viking Hoard, layer by layer
, 2017 Hold on to your Viking helmet; you’re about to dig, layer by layer, into one of the most extraordinary Viking hoards ever found on the British Isles – the Galloway Hoard – with Dr Martin Goldberg, Senior Curator at National Museums ...
Goldberg, D Martin
core
, 2016 Colloidal assembly is one of the highly active areas in nanoscale science and technology as it plays an important role in organizing nanoscale building blocks into hierarchical and functional systems for practical applications.
Guihua Yu (1440559) +4 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Pharmaceuticals, 2018 Currently, one of the greatest health challenges worldwide is the resistance to antibiotic drugs, which has led to the pursuit of new alternatives for the recovery of biological activity, where the use of different types of nano-systems has shown an ...
Lina M. Arévalo +3 more
doaj +1 more source
, 2016 Water-soluble poly(ferrocenylsilane) (PFS) and poly(styrenesulfonate) (PSS) of alternating charge are shown to self-assemble in a layer-by-layer fashion on primed Au, Si, and quartz substrates to create the first examples of organic−organometallic ...
K. Nicole Power-Billard (3055254) +9 more
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
The onset of instability in unsteady boundary-layer separation
, 1996 The process of unsteady two-dimensional boundary-layer separation at high Reynolds number is considered. Solutions of the unsteady non-interactive boundary-layer equations are known to develop a generic separation singularity in regions where the ...
K. W. Cassel +5 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source