Results 71 to 80 of about 642,256 (252)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Layer-by-layer functionalisation of composite membranes for bone in vivo regeneration

, 2017
The data represent the physico-chemical and biological characterisation of electrospun membranes functionalised by Layer-by-layer assembly.
J Callaghan (7836350), P Gentile (7835690), AM Ferreira (7835687)   +2 more
core   +1 more source

Layer-by-Layer Assembly of CeO₂ Nanoparticle/Bovine Serum Albumin Films for Bone Regeneration

, 2023
As a critical factor in bone regeneration, oxidative stress affects the effectiveness of implantation seriously. Construction of bioactive coatings with ideal antioxidative and osteogenic activities is essential for the repair of bone injury.
Shuoshuo Yang (6872285), Hailing Li (126961), Zhonghong Gao (1991428), Zhonghong Gao, Hailing Li, Shuoshuo Yang   +5 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Preparation of lignosulfonate‐based nanofiltration membranes with improved water desalination performance

Engineering in Life Sciences, 2021
Pulping and papermaking generate large amounts of waste in the form of lignosulfonates which have limited valorized applications so far. Herein, we report a novel lignosulfonate‐based nanofiltration membrane, prepared by using polyethylenimine (PEI) and ...
Wangqu Liu, Xin Geng, Saisai Li, Xia Zhan, Jiding Li, Luying Wang, Jiandu Lei   +6 more
doaj   +1 more source

Layer-by-Layer Assembly of Polyaniline Nanofibers and MXene Thin-Film Electrodes for Electrochemical Energy Storage

, 2019
The growing demand for compact energy storage devices may be met through the use of thin-film microbatteries, which generally rely on charge storage in thin or conformal layers.
Paraskevi Flouda (8115392), Miladin Radovic, Zeyi Tan (8115395), Shaoyang Wang (5532662), Alexandra Easley (6165731), Jodie L. Lutkenhaus, Xiaofei Zhao (2129077), Alexandra Easley, Junyeong Yun, Evan Prehn, Junyeong Yun (1501273), Micah J. Green (1421404), Zeyi Tan, Paraskevi Flouda, Ian Echols (4822347), Evan Prehn (8115398), Shaoyang Wang, Jodie L. Lutkenhaus (1357074), Xiaofei Zhao, Micah J. Green, Miladin Radovic (6239030), Ian Echols, Goangseup Zi (1501270), Goangseup Zi   +23 more
core   +1 more source

Layer-by-Layer Assembly of a Polysaccharide “Armor” on the Cell Surface Enabling the Prophylaxis of Virus Infection

, 2022
Airborne pathogens, such as the world-spreading severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), cause global epidemics via transmission through the respiratory pathway.
Ming Ke (3796756), Youqian Xu (4458427), Ju Tan (1579834), Guanyuan Yang (12699539), Yinhua Qin (12487610), Zhiqiang Nie (1719160), Xiaohang Qu (12487613), Yinghao Li (2850890), Xinxin Li (281237), Yonghong Fan (4407628), Chuhong Zhu (44548)   +10 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Layer-by-Layer Assembly of Graphene Oxide Nanoplatelets Embedded Desalination Membranes with Improved Chlorine Resistance

, 2019
Membranes with polyamide thin film active layer are used in reverse osmosis based water desalination applications. Incorporation of graphene oxide nanoplatelets (GONPs) in the polyamide layer can alter the surface characteristics, permeability ...
Santanu Kundu (4408402), Mahsa Abbaszadeh (6711487), Daniel Krizak (6711490)   +2 more
core   +2 more sources