Results 21 to 30 of about 902 (216)

Dike propagation through layered rocks [PDF]

Journal of Geophysical Research: Solid Earth, 2009
Dike penetration through a succession of upper crustal layers with different densities is studied with a new numerical code. For an individual layer to significantly affect dike ascent, its thickness must be of order 1 when scaled to the characteristic length‐scale for the inflated nose region that develops below the dike tip.
Taisne, B., Jaupart, C.
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Investigation on the pullout bearing properties and stress characteristics of fully grouted bolts in layered rock mass

Energy Science & Engineering
Coal‐measure strata is a typical layered structure, a better understanding of the bearing characteristics of fully grouted bolts in layered rock mass is of great significance for roadway support.
Yunlou Du, Yujiang Zhang, Guorui Feng, Lujin He, Xihong Zhang   +4 more
doaj   +1 more source

Tunnel surrounding rock plastic zone in the layered rock mass with the elastoplastic theory

Shuiwen dizhi gongcheng dizhi
Existing theoretical studies on the plastic zone of tunnel surrounding rock mainly focus on the circular tunnel in the isotropic rock mass, with limited attention paid to layered rock mass.
Shudong ZHOU, Tongwei ZHANG, Xinsheng WANG, Xiaoxiao MA, Hongyan LIU   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Research on Damage Evolution Mechanism of Layered Rock Mass under Blasting Load

Buildings
Rock mass consists of many discontinuities, such as faults, joints, etc., and layered joints are a common kind of rock mass structure. The joints affect the stress wave propagation, and blasting is an economical and efficient rock fragmentation method ...
Lixiang Xie, Jiahao Zhang, Dongyu Yang, Yanjun Qi, Linjun Wu, Hongyun Chen   +5 more
doaj   +1 more source

Semi-automated classification of layered rock slopes using digital elevation model and geological map

Open Geosciences, 2023
Layered rock slopes are the most widely distributed slopes with the simplest structure. The classification of layered rock slopes is the basis for correctly analyzing their deformation and failure mechanisms, evaluating their stability, and adopting ...
Shang Hao, Wang Da-Hai, Li Meng-Yuan, Ma Yu-Hong, Yang Shi-Peng, Li An-Bo   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Fracture and Damage of Slit Charge Blasting in the Layered Rock Mass

Applied Sciences
Directional fracture blasting technology of the slit charge has broad application prospects in the drilling and blasting construction of the layered rock mass.
Chenxi Ding, Hong Su, Haitao Yang, Chenglong Xiao   +3 more
doaj   +1 more source