Results 101 to 110 of about 52,889 (308)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 1991 This report wishes to define what layering is. It was found to be categorised into three parts: literal, phenomenal, metaphorical. Layering is the placement of elements in such a way that one is aware of the juxtaposition either literally, phenomenally ...
Gray, Tracey
core
The Grammaticalization of Modal Verbs in Brazilian Portuguese: A Synchronic Approach
Journal of Portuguese Linguistics, 2016 This paper analyzes the grammaticalization of modal verbs in Brazilian Portuguese from a synchronic perspective. It takes as its point of departure the hypothesis that grammaticalization is a process in which linguistic elements widen their scope.
Kees Hengeveld +1 more
doaj +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Layering the Semantic Web: Problems and Directions
, 2002 The Resource Description Framework and the Resource Description Framework Schema Specification are supposed to be the foundations of the Semantic Web, in that all other Semantic Web languages are to be layered on top of them.
Dieter Fensel, Peter F. Patel-Schneider
core +1 more source
Below and Beyond the Map: Stories of Urban Regeneration of the Barcelona Waterfront
LandUrban regeneration is often presented by those responsible as an unquestionable success story. Barcelona’s transformation from the mid-1980s, with its great Olympic momentum and successive attempts to maintain its international status, is perhaps one of ...
Núria Benach, Núria Font-Casaseca
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Charge layering in polar liquids
, 1992 Evidence of a moderate charge layering is found in simulated liquids of rigid polar molecules (acetone and acetonitrile), while this correlation is absent if molecules are flexible (1,2-dimethoxyethane).
G. Morosi +7 more
core +1 more source