Results 101 to 110 of about 1,988,983 (304)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Retention of carotenoids in egg yolks of laying hens supplemented with heterotrophic Chlorella

open access: yesCzech Journal of Animal Science, 2013
The present study investigated the effect of 1 and 2% feed supplementation with biomass of Chlorella grown through heterotrophic fermentation on the concentration of total and individual carotenoids in egg yolks. A total of twenty-four Hisex Brown laying
V. Kotrbáček   +6 more
doaj   +1 more source

Layer codes

open access: yesNature Communications
80 pages, 33 figures; v2 substantial changes to improve ...
Dominic J. Williamson, Nouédyn Baspin
openaire   +4 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Layers of Looking

open access: yesi-Perception, 2011
The films that I make are part documentary, part film essay, part visual poem. They are created out of a series of up to 30 drawings that are animated. The process from research to completion takes about 2 years, and at the end of it there is a film and a number of drawings that can be exhibited.
openaire   +3 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Feeding effect of dandelion powder and astaxanthin in diet of layers

open access: yesSiliao yanjiu, 2021
The experiment studied the effect of dandelion powder and astaxanthin on performance and egg quality of laying hens. 450 Hyline brown layers of 45-week-old with similar body weight were randomly divided into nine numerically-equal treatment groups, with ...
Jian BAI
doaj  

Creating New Vector Layers in QGIS 2.0

open access: yes, 2013
In this lesson you will learn how to create vector layers based on scanned historical maps. In Intro to Google Maps and Google Earth you used vector layers and created attributes in Google Earth.
Daniel Macfarlane   +2 more
core  

On the non-classical problem of thermal conduction on anisotropic layers in R3

open access: yes, 2009
International audienceWe propose a solution methodology for boundary problems of parabolic and hyperbolic thermal conduction on anisotropic layers in R.
Filshtinskii, LA   +5 more
core   +1 more source

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