Results 81 to 90 of about 68,390 (95)

Abstract 3640: Treatment strategies using anti-PD1/PD-L1 (anti-PD) and BRAF/MEK inhibitor (BRAFi) therapy: a retrospective study comparing sequential vs. concurrent administration in BRAF-mutated metastatic melanoma (BMMM)

Clinical research, 2018
Background: It is unclear whether anti-PD and BRAFi therapy should be administered sequentially or concurrently in patients (pts) with BMMM, although clinical trials using varying strategies are ongoing.
R. Amaria, V. Trinh, J. Gu, S. McIntyre, C. T. Cabala, Rinata Simien, A. Diab, H. Tawbi, M. Davies, M. Wong, P. Hwu, I. Glitza, S. Patel, W. Hwu   +13 more
semanticscholar   +1 more source

Comment on "ISO estimates of noise-induced hearing impairment" [J. Acoust. Soc. Am. 45(6), 3640-3646 (2019)].

Journal of the Acoustical Society of America
ISO/DIS 1999 document, titled "Estimation of noise-induced hearing loss" (NIHL) [ISO (2024). (International Organization for Standardization, Geneva, Switzerland)] was published in June 2024.
Olaf Michel, Martin Liedtke, Florian Schelle, Andrea Wolff, Sandra Dantscher   +4 more
semanticscholar   +1 more source

Abstract 3640: Mapping drug-gene interactions in cancer with large language models

Cancer Research
Understanding drug-gene relationships is critical for advancing targeted cancer therapies, identifying opportunities for drug repurposing, and improving patient outcomes.
Ying-Ju Lai, Li-Ju Wang, Yufei Huang, Yu-Chiao Chiu   +3 more
semanticscholar   +1 more source

Abstract 3640: Novel humanized anti-Sialyl-Tn, anti-CD3 bispecific antibodies demonstrate tumor and T-cell specificity for immune activation at the tumor site

, 2017
Tumor-associated carbohydrate antigens (TACAs) historically have been challenging targets for antibody therapeutics. Sialyl-Tn (STn) is a cancer specific antigen that is expressed on the surface of carcinomas including ovarian, colon, prostate, and ...
D. Eavarone, Jillian Prendergast, P. Rao, J. Stein, Jeff Behrens, D. Dransfield   +5 more
semanticscholar   +1 more source

Abstract 3640: Discovery of quinazolinones as fibroblast growth factor receptor (FGFR1-4) kinase inhibitors

, 2015
Recent data obtained in several tumor types have identified Fibroblast Growth Factor signaling as a key factor in the molecular pathology of a number of cancers1.
Olivier Querolle, P. Angibaud, Helene Colombel, Virginie Caron, I. Pilatte, V. Poncelet, N. Esser, R. Gilissen, P. King, L. Meerpoel, T. Verhulst, B. Wroblowski, J. Vialard, C. Murray, D. Rees, Anita Reningovolo, G. Saxty   +16 more
semanticscholar   +1 more source

Abstract 3640: IL-9 is involved in the establishment of a tolerogenic milieu that prevents anti-tumor immunity

, 2014
IL-9 is a Th2 cytokine associated with T regulatory cell function, parasite expulsion and allergic airway inflammation. In many tumors IL-9 contributes to the establishment of a tolerogenic / immunosuppressive environment or acts directly to drive tumor ...
D. Hoelzinger, A. Dominguez, P. Cohen, Sandra J. Gendker   +3 more
semanticscholar   +1 more source

Abstract 3640: Age-related DNA methylation in normal breast tissues.

, 2013
Age-related DNA methylation in normal breast tissues It is well established that age is a key risk factor for breast cancer, with increasing incidence associated with older age.
K. Johnson, Amanda K. Jensen, M. A. Murphy, D. Koestler, B. Christensen   +4 more
semanticscholar   +1 more source

Spatial and Temporal Clustering of Large Earthquakes on Upper-Plate and Subduction Thrust Faults Along the Southern Hikurangi Subduction Margin, Aotearoa-New Zealand

Bulletin of The Seismological Society of America (BSSA)
Large (≥Mw 6.5) earthquakes recorded in active fault systems are commonly clustered in space and time, which presents challenges for time-dependent seismic hazard modeling.
Jade Humphrey, A. Nicol, A. Howell, N. Litchfield, R. Langridge, Russell J. Van Dissen, Camilla E. Penney, B. Fry   +7 more
semanticscholar   +1 more source

Development of a Simulator with Two Degrees of Freedom of the Direction System of Massey-Ferguson’s 3640 Agricultural Tractors

Advances in Intelligent Systems and Computing, 2019
André Mixán, Andy Mamani, Leonardo Vinces, C. del Carpio   +3 more
semanticscholar   +1 more source

The 3640–3510 BC rhyodacite eruption of Chachimbiro compound volcano, Ecuador: a violent directed blast produced by a satellite dome

Bulletin of Volcanology, 2014
B. Bernard, S. Hidalgo, C. Robin, B. Beate, Jenny Quijozaca   +4 more
semanticscholar   +1 more source