Results 91 to 100 of about 38,124 (242)

Gastrointestinal microbiota and barrier integrity in individuals who develop exertional heat illness and pair‐matched controls: A prospective observational cohort study

Experimental Physiology, EarlyView.
Abstract It has been hypothesised that the composition of the gastrointestinal (GI) microbiota contributes to exertional heat illness (EHI) aetiology, but relevant empirical data in humans are lacking. Utilising a unique prospective study design, stool samples and resting blood samples were obtained from 550 individuals prior to (within 3 days ...
Alex A. M. Gould, Neil P. Walsh, Michael J. Tipton, Michael J. Zurawlew, Samuel C. Robson, Janis K. Shute, Joy E. M. Watts, Hayley C. Tyson, Megan R. Robinson, Andrew J. Roberts, Alex J. Rawcliffe, Ross Hemingway, Jo Corbett   +12 more
wiley   +1 more source

The Evolution of Breast Cancer Detection: A Review of Imaging, Machine Learning, and Multimodal Strategies

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Breast cancer is still a serious problem in the world arena, where its early and prompt detection is the most important factor in improving patient prognosis and survival. The use of traditional diagnostic techniques, such as imaging (e.g., mammography and ultrasound) and subsequent histopathological examination, is the mainstay, which ...
Likhon Chandra Sarkar, Farida Siddiqi Prity, Farhad Hussain, Anup Talukder, Mirza Raquib, Sharmina Rahman, MD Jiabul Hoque   +6 more
wiley   +1 more source

Fragmentation by Dams and Habitat Quality Affect Body Condition of a Small Characid in a Neotropical System

Ecology of Freshwater Fish, Volume 35, Issue 4, October 2026.
ABSTRACT The structure of stream networks naturally fragments freshwater habitats, but this complexity is increasingly intensified by dams and reservoirs. How anthropogenic fragmentation interacts with natural isolation gradients to affect fish populations remains poorly understood.
Ana Carolina Daldegan, Yan F. F. Soares, Paulo Vitor Rabelo, Vinicius Urbano, Bruno E. Soares, Juan P. Quimbayo, Laura B. Paula‐Souza, Carmino Emidio Junior, Amanda S. Vasconcelos, Débora L. Ferreira, Veronica Slobodian, Eduardo Bessa, Murilo S. Dias   +12 more
wiley   +1 more source

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence

JOR SPINE, Volume 9, Issue 3, September 2026.
A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, Dmitriy Sheyn   +14 more
wiley   +1 more source

Transgenic Conversion of Omega‐6 to Omega‐3 Fatty Acids via fat‐1 Reduces Obesity‐Related Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 3, September 2026.
We investigated whether transgenic conversion of omega‐6 to omega‐3 fatty acids mitigates obesity‐associated intervertebral disc (IVD) degeneration. Using fat‐1 mice on a high‐fat diet, we observed that endogenous omega‐3 production prevented diet‐induced disc pathology, metabolic dysfunction, and reduced systemic inflammation, indicating a protective ...
Shirley N. Tang, Kristin L. Lenz, Emma Shen, Collin Murray, Nikitha Ada, Sarada Prasad, Mohammed Kuziez, Farshid Guilak, Arin K. Oestreich   +8 more
wiley   +1 more source

Transient formation of supramolecular complexes between hyaluronan and oligopeptides at submicromolar concentration

Communications Chemistry
Charged polymer interactions govern biological and technological processes by altering the structure and dynamics of surrounding water. Studying these interactions across a broad concentration range is challenging, particularly at submicromolar levels ...
Miguel Riopedre-Fernandez, Bingxin Chu, Anna Kuffel, Arianna Marchioro, Denys Biriukov, Hector Martinez-Seara   +5 more
doaj   +1 more source

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source

Aktualne standardy diagnostyki i leczenia dolegliwości bólowych miednicy ze źródłem w stawach krzyżowo-biodrowych = Current standards for diagnosis and treatment of pain with pelvis source in sactoiliac joints

Journal of Education, Health and Sport, 2017
Cichosz Michał, Kochański Bartosz, Dziweżek Ireneusz, Kobylańska Marzena, Polczyk Artur, Kałużny Krystian, Zukow Walery. Aktualne standardy diagnostyki i leczenia dolegliwości bólowych miednicy ze źródłem w stawach krzyżowo-biodrowych = Current ...
Michał Cichosz, Bartosz Kochański, Ireneusz Dziweżek, Marzena Kobylańska, Artur Polczyk, Krystian Kałużny, Walery Zukow   +6 more
doaj  

Human In Vivo Disc Mechanics in Flexion, Extension, and Diurnal Loading With Aging and Degeneration

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background The intervertebral disc serves a critical role in spine function, but with aging and degeneration the disc undergoes changes that alter disc mechanics, and degeneration is often implicated in low back pain. The objective of this study was to quantify and evaluate the impact of aging and degeneration on in vivo lumbar disc mechanics ...
Harrah R. Newman, John M. Peloquin, Edward J. Vresilovic, Dawn M. Elliott   +3 more
wiley   +1 more source