Results 81 to 90 of about 62,435 (224)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

LBP and Color Descriptors for Image Classification

, 2012
Four novel color Local Binary Pattern (LBP) descriptors are presented in this chapter for scene image and image texture classification with applications to image search and retrieval. Specifically, the first color LBP descriptor, the oRGB-LBP descriptor,
Abhishek Verma, Sugata Banerji, Liu, Chengjun, Verma, Abhishek, Banerji, Sugata, Chengjun Liu   +5 more
core   +1 more source

Alamandine/MrgD pathway modulates gut–bone marrow axis in ageing

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ageing is associated with colon epithelial barrier disruption and up‐regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut–
Kishore Chittimalli, Henryata E. Rozario, Victor Martinez, Zachary L. McAdams, Stephen A. Adkins, Aaron C. Ericsson, Yagna P. R. Jarajapu   +6 more
wiley   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Pathogenic GBA1 Variants and their Interaction with the Gut–Microbiota–Brain Axis in Parkinson's Disease

Movement Disorders, EarlyView.
Helen Dainton‐Howard, Phillip Engen, Kristi Lawrence, Maliha Shaikh, Mohamad Abdel‐Mohsen, Stefan Green, Ankur Naqib, Neha Joshi, Michelle Villanueva, Alana Kirby, Ali Keshavarzian, Christopher Goetz   +11 more
wiley   +1 more source

Endodontic Treatment of Apical Periodontitis Mitigates Systemic Inflammation and Restores the Blood–Brain Barrier Integrity in an In Vitro Model

International Endodontic Journal, EarlyView.
ABSTRACT Aim A growing body of research supports an association between periapical inflammation and an increased risk of various systemic effects. However, there is currently no scientific evidence demonstrating a causal relationship between this inflammation and changes in epithelial or endothelial permeability in patients with apical periodontitis ...
Loredana Bergandi, Mario Alovisi, Elena Tachis, Nicola Scotti, Andrea Baldi, Iris Chiara Salaroglio, Sabrina Digiovanni, Lorena Charrier, Francesca Silvagno, Damiano Pasqualini   +9 more
wiley   +1 more source

Periodontitis and Rheumatoid Arthritis—Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
Periodontitis and rheumatoid arthritis are linked via the two‐hit model whereby early periodontal inflammation can lead to autoantibody production capable of interacting with inflamed synovial tissues. Subsequent systemic inflammation can exacerbate the periodontal inflammatory response and bacterial dysbiosis leading to further autoantibody production
Mark Bartold, Chia Wei Cheah, Rathna Devi Vaithilingam   +2 more
wiley   +1 more source

Comparative Analysis of Human Detection using Depth Data and RGB Data with Kalman Filter: A Study on Haar and LBP Methods

JOIV: International Journal on Informatics Visualization
Accurate human detection in video streams with occlusions, illumination variances, and varying distances is crucial for various applications, including surveillance, human-computer interaction, and robotics. This study investigates the performance of two
Fira Aulia, Hary Oktavianto, Bima Sena Bayu Dewantara   +2 more
doaj   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Imbalance of lipopolysaccharide-binding systems as a potential link in pathogenesis of rheumatoid arthritis

Медицинская иммунология
Lipopolysaccharide (LPS, endotoxin) of Gram-negative bacteria is a strong activator of innate immune system and inducer of systemic and local inflammation.
I. A. Yatskov, V. A. Beloglazov, K. V. Bubley   +2 more
doaj   +1 more source