Results 161 to 170 of about 22,711 (241)

Quantitative Disk and Metabolic Bone PET‐MRI for Understanding Disk‐Endplate Crosstalk in Degeneration of the Lumbar Spine

JOR SPINE, Volume 9, Issue 2, June 2026.
ABSTRACT Objectives The aim of this investigation was to explore the association between disk degeneration, quantified by Pfirrmann grades and T1rho as a marker of hydration, and bone remodeling in the vertebral endplate quantified by Na[18F]F uptake on PET.
Virginie Kreutzinger, Katharina Ziegeler, Misung Han, Cynthia T. Chin, Rupsa Bhattacharjee, Isabelle Remick, Emma Bahroos, Sharmila Majumdar   +7 more
wiley   +1 more source

MRI T2 Relaxation Time of the Intervertebral Disc: Repeatability, the Effect of Time of Day, and Unloaded Rest

JOR SPINE, Volume 9, Issue 2, June 2026.
T2 relaxation time is a commonly used MRI measure of intervertebral disc degeneration. This study investigated the repeatability, as well as the effects of time of day and rest on T2 relaxation time. T2 time repeatability was primarily driven by acquisition factors while time of day and rest changes did not exceed within subject variability. Thus, this
Mackenzie N. Conner, Harrah R. Newman, John M. Peloquin, Edward J. Vresilovic, Dawn M. Elliott   +4 more
wiley   +1 more source

Diagnostic Features of Discogenic Low Back Pain: A Narrative Review and Suggested Areas for Future Research and Clinical Practice

JOR SPINE, Volume 9, Issue 2, June 2026.
ABSTRACT Background Chronic low back pain is a leading cause of global disability, with discogenic low back pain (DLBP), mechanically stimulated pain arising from the intervertebral disc, representing an important but often under‐recognized subtype. DLBP arises from chronic structural and metabolic changes within the intervertebral disc, leading to ...
William Roger Peters, Ashish D. Diwan, Mario Giuseppe Zotti   +2 more
wiley   +1 more source

Comparative Analysis of Dual‐miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair

JOR SPINE, Volume 9, Issue 2, June 2026.
Nucleus pulposus (NP) and bone marrow derived stem cells (BMSCs) transfected with miRNA‐149‐5p‐mimic and 221‐3p‐inhibitor were evaluated in goat monolayer, microtissue, and ex vivo organ cultures of mild degeneration. miRNA‐treated NP cells demonstrated an anti‐catabolic and pro‐discogenic response in organs, highlighting its potential as a ...
Tara Ní Néill, Niamh Wilson, Jake McDonnell, Fergal J. O'Brien, Caroline M. Curtin, James E. Dixon, Pieter A. J. Brama, Conor T. Buckley   +7 more
wiley   +1 more source

Pre‐Conditioned Bone Marrow Mesenchymal Stromal Cell‐Derived Secretome Exerts an Anti‐Inflammatory Effect on Degenerative Nucleus Pulposus Cells In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
IL‐1β‐preconditioned BM‐MSC‐derived secretome counteracts inflammation‐driven degeneration in hNPCs. BM‐MSCs were preconditioned with IL‐1β (10 ng/mL) for 24 h, and the resulting secretome (BM‐MSCsec) was collected. Degenerative hNPCs cultured in a 3D alginate bead model were exposed to IL‐1β to reproduce an inflammatory degenerative microenvironment ...
Veronica Tilotta, Gianluca Vadalà, Luca Ambrosio, Giuseppina Di Giacomo, Claudia Cicione, Fabrizio Russo, Rocco Papalia, Vincenzo Denaro   +7 more
wiley   +1 more source

Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity

JOR SPINE, Volume 9, Issue 2, June 2026.
Human intervertebral disc nutrient microenvironment. Changes observed in microenvironmental profile as a result of degeneration outlined on upper vertebral body with ranges of each species as reported in previous studies. Oxygen, glucose, and lactate gradients are profiled across the lower disc in both healthy and degenerated states.
Niamh Wilson, Tara Ní Néill, Jake McDonnell, Emily McDonnell, Stacey Darwish, Joseph S. Butler, Conor T. Buckley   +6 more
wiley   +1 more source

Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou, Sheng He, Lili He, Kun Liu, Wen Tang, Deming Wang, Jing Gui, Zhiying Zeng, Yan Wang, Wenjie Liu, Ren Jing   +10 more
wiley   +1 more source

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, Volume 1, Issue 2, Page 63-89, June 2026.
ABSTRACT The growing recognition of the microbiome’s role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

‘There's No Improvement. I'm Still Bedridden’: Recovery After Hospital Admission for Low Back Pain and Alignment With Patient Expectations

Musculoskeletal Care, Volume 24, Issue 2, June 2026.
ABSTRACT Background Patients with non‐serious low back pain (LBP) may present to hospital emergency departments expecting high‐value care when community healthcare options are perceived as inaccessible or ineffective. Objectives This study explored the experiences and expectations of patients following a LBP‐related admission to provide insight into ...
Joseph F. Orlando, Matthew Beard, Anne L. J. Burke, Michelle Guerin, Saravana Kumar   +4 more
wiley   +1 more source

The Core Components and Instruments of the Therapeutic Relationship in Musculoskeletal Physiotherapy: A Systematic Integrative Review

Musculoskeletal Care, Volume 24, Issue 2, June 2026.
ABSTRACT Background The therapeutic relationship is meaningful and valuable to patients in rehabilitation and is positively associated with improved rehabilitation outcomes. Despite its central role, a comprehensive understanding of what constitutes the therapeutic relationship in physiotherapy and how it can be assessed is yet to be achieved ...
Sini Puustinen, Tarja Kvist, Minna Stolt
wiley   +1 more source