Results 211 to 220 of about 374,900 (245)
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Identification of losartan degradates in stressed tablets by LC-MS and LC-MS/MS
Journal of Pharmaceutical and Biomedical Analysis, 1999Three unknown peaks were observed in the severely stressed losartan tablets (at 40 degrees C and 75% relative humidity for 3 years) analyzed by a stability indicating HPLC method. The sample solutions were subjected to liquid chromatography-tandem mass spectrometric (LC-MS/MS) analysis to obtain the chemical identities of these potential degradates ...
Z, Zhao +4 more
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Characterization of PEGylated Biopharmaceutical Products by LC/MS and LC/MS/MS
2012PEGylation of peptide and proteins is an important method of improving their pharmacokinetic, pharmacodynamic, and immunological profiles, and thus enhancing their therapeutic effect. However, PEGylation of peptides and proteins creates significant challenges for detailed structural characterization, such as PEG heterogeneity, site of PEG addition, and
Lihua, Huang, P Clayton, Gough
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Lc–Ms Systems For Quantitative Bioanalysis
Bioanalysis, 2012LC-MS has become the method-of-choice in small-molecule drug bioanalysis (molecular mass
Dongen, W.D. van, Niessen, W.M.A.
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2013
Peak extraction from raw data is the first step in LC-MS data analysis. The quality of this procedure is important since it affects the quality and accuracy of all subsequent analysis such as database searches and peak quantitation. The most important and most accurately measured physical entity provided by mass spectrometers is m/z values which need ...
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Peak extraction from raw data is the first step in LC-MS data analysis. The quality of this procedure is important since it affects the quality and accuracy of all subsequent analysis such as database searches and peak quantitation. The most important and most accurately measured physical entity provided by mass spectrometers is m/z values which need ...
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2010
Metabolomics involves qualitative and/or quantitative analysis of hundreds of metabolites in a complex sample. As most of the metabolites are polar in nature (for example, amino acids, nucleotides, carboxylic acids), their chromatographic separation and analysis present a difficult challenge. Recently, hydrophilic interaction chromatography (HILIC) has
Sunil, Bajad, Vladimir, Shulaev
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Metabolomics involves qualitative and/or quantitative analysis of hundreds of metabolites in a complex sample. As most of the metabolites are polar in nature (for example, amino acids, nucleotides, carboxylic acids), their chromatographic separation and analysis present a difficult challenge. Recently, hydrophilic interaction chromatography (HILIC) has
Sunil, Bajad, Vladimir, Shulaev
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Bioanalytical LC–MS of Therapeutic Oligonucleotides
Bioanalysis, 2011Therapeutic oligonucleotides (OGNTs) are important biopharmaceutical drugs for the future, due to their ability to selectively reduce or knockout the expression of target genes. For the development of OGNTs, reliable and relatively high-throughput bioanalytical methods are required to perform the quantitative bioanalysis of OGNTs and their metabolites ...
van Dongen, W.D., Niessen, W.M.A.
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LC-MS and LC-MS-MS for Biomedical Analyses
1988The identification of components separated by LC* can be done either by preparative chromatography and off-line MS or, with advantages, by on-line LC-MS.θ The moving belt and DLI are the oldest commercially available interfaces. The belt allows EI, CI or FAB to be chosen for ionisation, but samples may suffer from thermal degradation. DLI is limited to
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2011
This chapter describes a protocol to analyze polyamines without any derivatization steps utilizing LC-MS/MS. Polyamines are separated by reversed phase LC prior MS analysis using heptafluorobutyric acid as MS compatible volatile ion-pairing agent, and selective and sensitive MS detection is performed using MS/MS in selected reaction monitoring mode.
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This chapter describes a protocol to analyze polyamines without any derivatization steps utilizing LC-MS/MS. Polyamines are separated by reversed phase LC prior MS analysis using heptafluorobutyric acid as MS compatible volatile ion-pairing agent, and selective and sensitive MS detection is performed using MS/MS in selected reaction monitoring mode.
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2018
LC-MS untargeted analysis is a valuable tool in the field of metabolic profiling (metabonomics/metabolomics), and the applications of this technology have grown rapidly over the past decade. LC-MS offers advantages over other analytical platforms such as speed, sensitivity, relative ease of sample preparation, and large dynamic range.
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LC-MS untargeted analysis is a valuable tool in the field of metabolic profiling (metabonomics/metabolomics), and the applications of this technology have grown rapidly over the past decade. LC-MS offers advantages over other analytical platforms such as speed, sensitivity, relative ease of sample preparation, and large dynamic range.
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LC-MS Method Development and Quantification by LC-MS in Marketed Formulations
Int. Jour. of Pharmamedix IndiaA simple, sensitive method has been developed for the quantitative estimation of Telmisartan (TELM) in the pharmaceutical formulations. Chromatographic separation was achieved on Merck chromolith RP18column (25mmX4.6mm). The flow rate was 0.5 ml/min and the injection volume was 5μL .An isocratic programme was used as ACN: water(0.1% formic acid, v/v ...
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