Results 101 to 110 of about 313,222 (315)

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Validation of an LC-MS/MS method for the determination of serum 17-hydroxyprogesterone

, 2022
openIntroduzione. Il 17-idrossiprogesterone (17-OHP) è un ormone steroideo, precursore del cortisolo che deriva dal colesterolo. La misurazione del 17-OHP può essere utilizzata per la ricerca, diagnosi e monitoraggio della sindrome surrenale-genitale ...
VERONESE, FRANCESCO
core  

LC-MS/MS data analysis with xcms

, 2020
The xcms software is a well established R package for the preprocessing of LC-MS-based untargeted metabolomics data. By extensively refactoring the package and re-using functionality and mass spectrometry (MS) data representation strategies from the ...
Neumann, Steffen (5286829), Witting, Michael, Rainer, Johannes, Neumann, Steffen, Rainer, Johannes (6879920), Witting, Michael (7361483)   +5 more
core   +1 more source

LC-MS raw data

, 2022
Raw data for liquid chromatography coupled with mass spectrometry (LC-MS) experiments along with skyline template used to extract peak area from raw data.
Yifan Huang (6603191)
core   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

LC-MS/MS chromatograms and standard curves of six neurotransmitters.

, 2023
LC-MS/MS chromatograms and standard curves of six neurotransmitters.
Asaka Yokota (16954562), Kazuhiro Tanabe (2924784)   +1 more
core   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

LC-MS/MS quantification of quorum sensing signalling molecules of Pseudomonas aeruginosa in different growth conditions

, 2023
reservedPseudomonas aeruginosa is a great threat for patients with cystic fibrosis, cancer, or AIDS since its infection may lead to morbidity and mortality in immunocompromised individuals. P. aeruginosa infections are difficult to treat due to bacterial
CHRISTIANTO, GEOVANNIE AUDREY MONIQE
core  

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source