Results 131 to 140 of about 313,222 (315)

A robust mass spectrometry method for rapid profiling of erythrocyte ghost membrane proteomes

Clinical Proteomics, 2018
Background Red blood cell (RBC) physiology is directly linked to many human disorders associated with low tissue oxygen levels or anemia including chronic obstructive pulmonary disease, congenital heart disease, sleep apnea and sickle cell anemia ...
Haddy K. S. Fye, Paul Mrosso, Lesley Bruce, Marie-Laëtitia Thézénas, Simon Davis, Roman Fischer, Gration L. Rwegasira, Julie Makani, Benedikt M. Kessler   +8 more
doaj   +1 more source

Metabolomics to unveil and understand phenotypic diversity between pathogen populations [PDF]

, 2010
Visceral leishmaniasis is caused by a parasite called Leishmania donovani, which every year infects about half a million people and claims several thousand lives. Existing treatments are now becoming less effective due to the emergence of drug resistance.
Breitling, Rainer,, Brunker, Kirstyn, Jean-Claude Dujardin, Breitling Rainer, Dujardin, Jean-Claude, Dujardin, Jean Claude, Scheltema, R.A., Coombs, Graham H.,, Rijal, Suman,, Brunker Kirstyn, Coombs, Graham H, Dujardin, J.-C., Rijal, S., Kirstyn Brunker, Coombs Graham H., Coombs, Graham H., Dujardin, Jean-Claude,, Dujardin Jean-Claude, Watson, David G, Jankevics, Andris,, Jankevics Andris, Saskia Decuypere, Watson, D.G., t'Kindt, R., Kindt, Ruben t’,, Suman Rijal, t'Kindt, Ruben, t'Kindt Ruben, Watson David G., Breitling, Rainer, Brunker, K., Breitling, R., Brunker, Kirstyn,, Scheltema Richard A., Jankevics, A., Richard A Scheltema, Geary, T.G., Rijal Suman, Decuypere, S., Graham H. Coombs, Coombs, G.H., Andris Jankevics, Decuypere, Saskia, Scheltema, Richard A, Scheltema, Richard A., David G. Watson, Watson, David G., Richard A. Scheltema, Rainer Breitling, Decuypere Saskia, Jankevics, Andris, Decuypere, Saskia,, Watson, David G.,, David G Watson, 't Kindt, Ruben, Rijal, Suman, Ruben t'Kindt, Scheltema, Richard A.,, Graham H Coombs   +58 more
core   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Annotating Nontargeted LC-HRMS/MS Data with Two Complementary Tandem Mass Spectral Libraries

Metabolites, 2018
Tandem mass spectral databases are indispensable for fast and reliable compound identification in nontargeted analysis with liquid chromatography–high resolution tandem mass spectrometry (LC-HRMS/MS), which is applied to a wide range of scientific ...
Herbert Oberacher, Vera Reinstadler, Marco Kreidl, Michael A. Stravs, Juliane Hollender, Emma L. Schymanski   +5 more
doaj   +1 more source

LC-MS/MS data for Zhang et al. NCB paper

, 2018
Data deposited here include different type of RNA modifications examined by LC-MS/MS (liquid chromatography–tandem mass spectrometry). Different types of RNA modifications in sperm RNA fractions (15-25nt, 30-40nt, 40-100nt and >100 nt) extracted from F0 ...
Yunfang Zhang (585611), Qi Chen (4907881)   +1 more
core   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Profiling oligosaccharide components in Polygonatum kingianum with potential anti-NAFLD activity using UPLC-Orbitrap-MS/MS technology

Food Hydrocolloids for Health
Polygonati Rhizoma serve as medicinal and edible plants rich in carbohydrates, with its polysaccharides extensively studied, while research on oligosaccharides remains limited regarding their structural and bioactive properties.
Hong Guo, Rui Yao, Jing Fan, Ying Wang, Lingzhi Zhang, Hua Sun, Xiaohan Guo, Jianbo Yang, Jingzhe Pu, Yazhong Zhang, Baozhong Duan, Jia Chen, Wenguang Jing, Xianlong Cheng, Feng Wei   +14 more
doaj   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source