Results 111 to 120 of about 38,748 (248)

Nontoxic-dose deoxynivalenol aggravates lipopolysaccharides-induced inflammation and tight junction disorder in IPEC-J2 cells through activation of NF-κB and LC3B

Food and Chemical Toxicology, 2020
Lipopolysaccharide (LPS) is the key factor in various intestinal inflammation which could disrupt the epithelial barrier function. Deoxynivalenol (DON), a well-known mycotoxin, can induce intestinal injury. However, the combined enterotoxicity of LPS and
Lei Ge, Ziman Lin, Guannan Le, Lili Hou, Xinru Mao, Shuiping Liu, Dandan Liu, F. Gan, Kehe Huang   +8 more
semanticscholar   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins [PDF]

, 2012
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved catabolic process necessary for normal recycling of cellular constituents and for appropriate response to cellular stress.
Chiariello, Mario, Colecchia, David, Dall\u27Armi, Claudia, Iavarone, Carlo, Piccioni, Federica, Rossi, Matteo, Sanzone, Sveva, Strambi, Angela, Verrotti Di Pianella, Arturo   +8 more
core   +1 more source

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late Life. [PDF]

, 2019
Rationale: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide. However, whether and how GDM exposure induces fetal programming of adult cardiac dysfunctional phenotype, especially the underlying epigenetic molecular mechanisms ...
Chen, Zewen, Gong, Lei, Li, Yong, Liu, Bailin, Xiao, Daliao, Zhang, Lubo, Zhang, Peng, Zhuang, Jian   +7 more
core  

Parkin-independent mitophagy controls chemotherapeutic response in cancer cells [PDF]

, 2017
Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with diverse pathologies, including cancer.
Bossowski, Jozef P., Chiche, Johanna, Marchetti, Sandrine, Mondragón, Laura, Obba, Sandrine, Proïcs, Emma, Ricci, Jean-Ehrland, Riley, Joel S., Rozier, Romain M., Rubio-Patiño, Camila, Tait, Stephen W.G., Verhoeyen, Els, Villa, Elodie, Zunino, Barbara   +13 more
core   +2 more sources

Role of COL1A1 and CD44 in Modulating JAK1/STAT3‐Mediated Autophagy for Spinal Cord Injury Recovery

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Spinal cord injury (SCI) is a severe trauma to the central nervous system that often leads to motor and sensory dysfunction in patients, severely affecting their quality of life. Autophagy plays a role in the pathological process of SCI, but the specific mechanism of autophagy in this case is unknown.
Chun‐Lei Li, Qian Zhang, Li Fang, Ling‐Yun Zhou   +3 more
wiley   +1 more source

Structural and Functional analysis of the GABARAP interaction motif (GIM) [PDF]

, 2016
© 2017 The Authors. Published under the terms of the CC BY 4.0 license. Through the canonical LC3 interaction motif (LIR), [W/F/Y]-X 1 -X 2 -[I/L/V], protein complexes are recruited to autophagosomes to perform their functions as either autophagy ...
Alexander Law, Alexandra Stolz, Andreas Kniss, Arvind C. Ravicahandran, David G. McEwan, Diana O. Rios-Szwed, Frank Löhr, Hironori Suzuki, Ivan Dikic, Renwick C.J. Dobson, Soichi Wakatsuki, Vladimir V. Rogov, Volker Dötsch   +12 more
core   +5 more sources

Visualizing bulk autophagy in vivo by tagging endogenous LC3B

Autophagy
Macroautophagy/autophagy plays a crucial role in maintaining cellular and organismal health, making the measurement of autophagy flux in vivo essential for its study. Current tools often depend on the overexpression of autophagy probes. In this study, we developed a knock-in mouse model, termed tfLC3-KI, by inserting a tandem fluorescent tag coding ...
Xiukui Gao, Yue Xiong, Hangbin Ma, Hao Zhou, Wei Liu, Qiming Sun   +5 more
openaire   +2 more sources