Results 101 to 110 of about 38,748 (248)

Prognostic value of TIGAR and LC3B protein expression in nasopharyngeal carcinoma

Cancer Management and Research, 2018
Autophagy, the process responsible for degrading cytoplasmic organelles to sustain cellular metabolism, has been associated with cancer initiation and progression. As TP53-induced glycolysis and apoptosis regulator (TIGAR) is among the important genes that can regulate autophagy, we aimed to investigate the correlation between the expression levels of ...
Min Wei, Jinxia Peng, Peng Wu, Ping Chen, Hongru Yang, Yongxia Cui, Linglin Yang   +6 more
openaire   +5 more sources

Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice

Scientific Reports, 2020
We generated a new transgenic mouse model that expresses a pHluorin-mKate2 fluorescent protein fused with human LC3B (PK-LC3 mice) for monitoring autophagy activity in neurons of the central nervous system.
Juan Alejandro Oliva Trejo, I. Tanida, Chigure Suzuki, S. Kakuta, N. Tada, Y. Uchiyama   +5 more
semanticscholar   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Exploring Arylidene–Indolinone Ligands of Autophagy Proteins LC3B and GABARAP

ACS Medicinal Chemistry Letters
ABSTRACTWe report the first structure-activity studies of arylidene-indolinone compoundGW5074which was reported as a ligand of autophagy-related protein LC3B. The literature has conflicting information on the binding affinity of this compound and there is some debate regarding its use as a component of autophagy-dependent degrader compounds.
Leveille, Alexandria N., Schwarzrock, Thomas, Brown, Hawley, True, Bennett, Plasencia, Joanet, Neudecker, Philipp, Üffing, Alina, Weiergräber, Oliver H., Willbold, Dieter, Kritzer, Joshua A.   +9 more
openaire   +4 more sources

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas

Oncotarget, 2016
Esophageal adenocarcinomas (EAC) are aggressive tumors with considerable rates of chemoresistance. Autophagy is a lysosome-dependent degradation process, characterized by the formation of vesicles called autophagosomes, and has been implicated in cancer.
Adams, Olivia Joan, Dislich, Bastian, Berezowska, Sabina Anna, Schläfli, Anna, Seiler, Christian A., Kröll, Dino, Tschan, Mario, Langer, Rupert   +7 more
openaire   +4 more sources

The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B

iScience, 2020
Summary AMFR/gp78 and USP13 are a pair of ubiquitin ligase and deubiquitinase that ensure the accuracy of endoplasmic reticulum-associated degradation (ERAD).
Yuanyuan Chu, Xing-qi Dong, Yingjin Kang, Jingnan Liu, Tao Zhang, Cuiwei Yang, Zhangshun Wang, Wa Shen, H. Huo, M. Zhuang, Junxia Lu, Yanfen Liu   +11 more
semanticscholar   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control [PDF]

, 2014
The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ...
Anholt R, Daniel East, Decaudin D, Garnier M, Gatliff J, Hirsch JD, James Crosby, Jemma Gatliff, Krueger KE, Li H, Michelangelo Campanella, Miettinen H, Okatsu K, Ozawa K, Papadopoulos V, Peter Parker, Robert Harvey, Rosella Abeti, Seneviratne MS, Sileikyte J, Snyder SH, Tamse CT, William Craigen   +22 more
core   +3 more sources

LSD1 Demethylates and Destabilizes Autophagy Protein LC3B in Ovarian Cancer

Biomolecules
Autophagy is a complex cellular process that can either promote or inhibit cancer progression and development, depending on the context and molecular regulation involved. This study investigates how LSD1 regulates autophagy in ovarian cancer by interacting with the autophagy protein LC3B.
Mingyang Li, Jie Feng, Kangrong Zhao, Ting Huang, Bowen Zhang, Yifan Yang, Aiqin Sun, Qiong Lin, Genbao Shao   +8 more
openaire   +3 more sources