Results 81 to 90 of about 38,748 (248)
Advanced Science, EarlyView.The functionalized starch modifies the mitochondrial surface and encapsulates resveratrol into the cavity of helices, facilitating a novel mitochondrial transplantation platform (MLSR). Upon internalization in recipient cells, MLSR triggers mitophagy and maintains positive autophagic flux through RIP1/RIP3 pathway inhibition.
Nisha Wang +12 more
wiley +1 more source
HUNK Phosphorylates Rubicon to Support Autophagy [PDF]
, 2019 Background: Autophagy is a catabolic cellular recycling pathway that is essential for maintaining intracellular homeostasis. Autophagosome formation is achieved via the coordination of the Beclin-1 protein complex.
Abt, Melissa +5 more
core +1 more source
O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer
Advanced Science, EarlyView.This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu +10 more
wiley +1 more source
Targeting quiescent leukemic stem cells using second generation autophagy inhibitors [PDF]
, 2019 In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs).
A Hamilton +42 more
core +2 more sources
Advanced Science, EarlyView.Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma +17 more
wiley +1 more source
CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1 [PDF]
, 2018 Macroautophagy/autophagy is an important intracellular mechanism for the maintenance of cellular homeostasis. Here we show that the CERKL (ceramide kinase like) gene, a retinal degeneration (RD) pathogenic gene, plays a critical role in regulating ...
Danna Jia +21 more
core +2 more sources
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma [PDF]
, 2018 Background: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM).
Chen, Yi +12 more
core +2 more sources
Quantifying autophagy using novel LC3B and p62 TR-FRET assays
PLOS ONE, 2018 Autophagy is a cellular mechanism that can generate energy for cells or clear misfolded or aggregated proteins, and upregulating this process has been proposed as a therapeutic approach for neurodegenerative diseases. Here we describe a novel set of LC3B-II and p62 time-resolved fluorescence resonance energy transfer (TR-FRET) assays that can detect ...
Alberto Bresciani +12 more
openaire +4 more sources
LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes
bioRxiv, 2020 Macroautophagy (hereafter referred to as autophagy) is a conserved process that promotes cellular homeostasis through the degradation of cytosolic components, also known as cargo.
Jose L. Nieto-Torres +5 more
semanticscholar +1 more source