Results 211 to 220 of about 12,462,002 (332)

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu   +10 more
wiley   +1 more source

Fra LCC til FSC

open access: yes, 2006
Business model development at low-cost and full-service airlines throughout the years has led to a departure from the original models. The low-cost model is shifting up-market to capture higher yield traffic, while the full-service model is adopting low-cost model elements to achieve optimization.
openaire   +1 more source

Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention

open access: yesCancer Medicine, Volume 15, Issue 2, February 2026.
Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa   +4 more
wiley   +1 more source

Whitings in the Red Sea

open access: yesThe Depositional Record, Volume 12, Issue 1, February 2026.
We present the first documentation of whitings in the Red Sea, observed in a lagoonal environment. These events are linked to cascading offshore dense waters that liberate trapped sea floor nutrients, triggering algal blooms and elevating alkalinity, which is buffered by direct CaCO3 precipitation—contributing to the accumulation of aragonite mud in ...
Manuel Ariza‐Fuentes   +8 more
wiley   +1 more source

Sidedness matters: Colon cancer outcomes in low-resource settings. [PDF]

open access: yesWorld J Clin Oncol
González-Montero J   +3 more
europepmc   +1 more source

Nexus of Whey Proteins, Gut Dysbiosis, and Colonic Health

open access: yesFood Science &Nutrition, Volume 14, Issue 2, February 2026.
Whey proteins possess antimicrobial and prebiotic properties that modulate gut microbiota by promoting beneficial bacteria like Bifidobacterium while suppressing pathogens. This modulation enhances short‐chain fatty acid production and strengthens intestinal barrier integrity, potentially alleviating dysbiosis‐related conditions such as colitis and ...
Tolulope Joshua Ashaolu   +4 more
wiley   +1 more source

Leukoencephalopathy, brain calcifications, and cysts (LCC): Two unique cases. [PDF]

open access: yesRare
Grafstein J   +7 more
europepmc   +1 more source

Prolactin Receptor Deficiency Promotes Hypomyelination in White Matter Tracts During Postnatal Central Nervous System Maturation in Mice

open access: yesGlia, Volume 74, Issue 2, February 2026.
Prolactin action is essential for proper myelination of white matter tracts during neonatal and prepubertal stages in mice. Lack of prolactin receptor (Prlr−/−) signaling leads to hypomyelination and impaired locomotor function. ABSTRACT A large wave of myelination in the central nervous system (CNS) of mammals occurs during postnatal development ...
Ana L. Ocampo‐Ruiz   +12 more
wiley   +1 more source

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