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Dendrimer Prodrugs [PDF]

open access: yesMolecules, 2016
The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field. Therefore, the use of dendrimer prodrugs as carrier for drug delivery, to improve pharmacokinetic properties of prototype, to promote drug sustained ...
Soraya da Silva Santos   +2 more
exaly   +5 more sources

Comparison of generation 3 polyamidoamine dendrimer and generation 4 polypropylenimine dendrimer on drug loading, complex structure, release behavior, and cytotoxicity

open access: yesInternational Journal of Nanomedicine, 2011
Naimin Shao1, Yunzhang Su1, Jingjing Hu2, Jiahai Zhang3, Hongfeng Zhang1, Yiyun Cheng1,41School of Life Sciences, East China Normal University, Shanghai, 2CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and ...
Shao N   +5 more
doaj   +1 more source

Dendrimer-protein interactions versus dendrimer-based nanomedicine [PDF]

open access: yesColloids and Surfaces B: Biointerfaces, 2017
Dendrimers are hyperbranched polymers belonging to the huge class of nanomedical devices. Their wide application in biology and medicine requires understanding of the fundamental mechanisms of their interactions with biological systems. Summarizing, electrostatic force plays the predominant role in dendrimer-protein interactions, especially with ...
Shcharbin, Dzmitry   +10 more
openaire   +4 more sources

In vitro and in vivo toxicity and histopathological evaluation of Gd(III)anionic Linear globular dendrimer second-generation G2-C595 nanoprobe [PDF]

open access: yesNanomedicine Journal, 2020
Objective(s): Toxico-histopathological studies are used to assess the toxic impacts of nanoparticles in organism exposure. The present study aimed to evaluate the prospective nano-cytotoxicity impacts of Gd(III)-anionic linear globular dendrimer second ...
Mehdi Mirzaei   +5 more
doaj   +1 more source

Rapid Bacterial Recognition over a Wide pH Range by Boronic Acid-Based Ditopic Dendrimer Probes for Gram-Positive Bacteria

open access: yesMolecules, 2021
We have developed a convenient and selective method for the detection of Gram-positive bacteria using a ditopic poly(amidoamine) (PAMAM) dendrimer probe.
Ayame Mikagi   +6 more
doaj   +1 more source

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

open access: yesBiomolecules, 2020
This article reviews progress over the past three decades related to the role of dendrimer-based, branch cell symmetry in the development of advanced drug delivery systems, aqueous based compatibilizers/solubilizers/excipients and nano-metal cluster ...
Donald A. Tomalia   +2 more
doaj   +1 more source

COMPUTER MODELING OF INTERACTION OF LYSINE DENDRIMER WITH EPITHALON PEPTIDES [PDF]

open access: yesНаучно-технический вестник информационных технологий, механики и оптики, 2018
Subject of Study.Dendrimers are hyperbranched polymeric molecules that regularly branch from a single center. Dendrimers are used in biomedical applications to deliver drugs and genetic material to cells.
D. N. Khamidova   +6 more
doaj   +1 more source

Size and Structure of Empty and Filled Nanocontainer Based on Peptide Dendrimer with Histidine Spacers at Different pH

open access: yesMolecules, 2021
Novel peptide dendrimer with Lys-2His repeating units was recently synthesized, studied by NMR (Molecules, 2019, 24, 2481) and tested as a nanocontainer for siRNA delivery (Int. J. Mol. Sci., 2020, 21, 3138).
Valeriy V. Bezrodnyi   +5 more
doaj   +1 more source

Helical micelle of an achiral surfactant from the template interaction with dendrimer

open access: yesGiant, 2023
The electrostatic interaction between of poly(amidoamine) (PAMAM) G9 dendrimer and an achiral surfactant, dodecylbenzenesulfonic acid (DBSA), leads to the formation of nucleosome-like structure, where the globular dendrimer molecule directs the DBSA ...
Yi-Cheng Lai   +7 more
doaj   +1 more source

Dendrimer-based drug delivery systems: history, challenges, and latest developments

open access: yesJournal of Biological Engineering, 2022
Since the first dendrimer was reported in 1978 by Fritz Vögtle, dendrimer research has grown exponentially, from synthesis to application in the past four decades.
Juan Wang   +4 more
doaj   +1 more source

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