Results 161 to 170 of about 6,085 (188)

Exploring imaging features of molecular subtypes of large cell neuroendocrine carcinoma (LCNEC) [PDF]

Lung Cancer, 2020
Radiological characteristics and radiomics signatures can aid in differentiation between small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC). We investigated whether molecular subtypes of large cell neuroendocrine carcinoma (LCNEC), i.e. SCLC-like (with pRb loss) vs.
S Sanduleanu, E J M Speel, A-M C Dingemans   +2 more
exaly   +7 more sources

Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder: a case report

Diagnostic Pathology, 2013
Abstract Neuroendocrine carcinoma of the urinary bladder is a rare entity, accounting less then 1% of urinary bladder malignancies. The vast majority of the neuroendocrine carcinoma of the urinary bladder is represented by small cell neuroendocrine carcinoma while just few cases of large cell neuroendocrine carcinoma (LCNEC) have been ...
Dario Giuffrida, Lorenzo Memeo, Eleonora Aiello   +2 more
exaly   +5 more sources

Is CK7 a Prognostic Marker in Pulmonary LCNEC? Evidence from a Limited Cohort Study †

Journal of Personalized Medicine
Objectives: While the treatment of non-small-cell lung carcinoma has improved rapidly, the treatment of pulmonary large-cell neuroendocrine carcinoma (LCNEC) remains underdeveloped. The use of immunohistochemistry allows for accurate risk stratification.
Georg Schlachtenberger, Servet Bölükbas, Alexander Quaas   +2 more
exaly   +4 more sources

Exploration of genetic characterization in hyperprogressive disease after immunotherapy retreatment in a patient with LCNEC: A case report

Human Vaccines and Immunotherapeutics
Immune checkpoint inhibitors (ICIs) have emerged as a promising therapeutic option for large cell neuroendocrine carcinoma (LCNEC). However, various studies have suggested a potential risk of hyperprogressive disease (HPD) in patients receiving ICI, which might be associated with gene alterations.
Qijin Shu, Liumei Shou
exaly   +6 more sources

Novel Mouse Cell Lines and In Vivo Models for Human High-Grade Neuroendocrine Lung Carcinoma, Small Cell Lung Carcinoma (SCLC), and Large Cell Neuroendocrine Carcinoma (LCNEC)

International Journal of Molecular Sciences, 2023
There is a clear need to expand the toolkit of adequate mouse models and cell lines available for preclinical studies of high-grade neuroendocrine lung carcinoma (small cell lung carcinoma (SCLC) and large cell neuroendocrine carcinoma (LCNEC)). SCLC and
Ramón García-Escudero, Corina Lorz, Sara Lázaro   +2 more
exaly   +2 more sources

Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens?

Histopathology, 2019
Aims Pulmonary large cell neuroendocrine carcinoma (LCNEC) is underdiagnosed on biopsy specimens. We evaluated if routine neuroendocrine immunohistochemical (IHC) stains are helpful in the diagnosis of LCNEC on biopsy specimens. Methods and results Using
Erik Thunnissen, Anne-Marie Dingemans, Michael A den Bakker   +2 more
exaly   +2 more sources

Pulmonary large cell neuroendocrine carcinoma (LCNEC): a population-based study addressing recent molecular-genetic advances and emerging therapeutic approaches

Clinical and Experimental Medicine, 2023
BackgroundLarge cell neuroendocrine carcinoma (LCNEC) of the lung is a rare, aggressive cancer most commonly found in the lungs but not exclusively, with a worse prognosis than non-small cell lung carcinomas.
Jaydira Del Rivero, Aman Chauhan, Hector A Mesa   +2 more
exaly   +2 more sources

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Comparison of chemotherapeutic efficacy between LCNEC diagnosed using large specimens and possible LCNEC diagnosed using small biopsy specimens

International Journal of Clinical Oncology, 2012
It is often difficult to diagnose large cell neuroendocrine carcinomas (LCNEC) of the lung using small biopsy specimens. Some recent studies attempted to diagnose LCNEC using biopsy specimens; in 2011, the International Association for the Study of Lung Cancer pathological panels suggested possible LCNEC as a diagnosis for LCNEC by using biopsy ...
Ichiro Ito, Nobuyuki Yamamoto, Hirotsugu Kenmotsu   +2 more
exaly   +3 more sources

Unknown primary large cell neuroendocrine carcinoma (LCNEC) in the mediastinum

General Thoracic and Cardiovascular Surgery, 2012
Unknown primary large cell neuroendocrine carcinoma (LCNEC) in the mediastinum is extremely rare. In this report, we present a case of a 53-year-old man with superior vena cava (SVC) syndrome who developed LCNEC in the middle mediastinum. His chief complaint was facial edema.
Masao Nakata, Riki Okita, Katsuhiko Shimizu   +2 more
exaly   +3 more sources

Two cases of combined large cell neuroendocrine carcinoma (LCNEC)

The Journal of the Japanese Association for Chest Surgery, 2016
Yuzo Takagi
exaly   +4 more sources