Results 171 to 180 of about 20,068,597 (246)

Safety and immunogenicity of a first-generation modified vaccinia virus Ankara-vectored SARS-CoV-2 vaccine candidate with mRNA-based booster vaccination: A phase 1 trial. [PDF]

Hum Vaccin Immunother
Fathi A, Dahlke C, Mayer L, Mellinghoff SC, Krähling V, Halwe S, Müller-Kräuter H, Fendel R, Kremsner P, Esen M, Klug M, Lütgehetmann M, Weskamm LM, MVA-SARS-2-S Study Group, Sutter G, Becker S, Hardtke S, Addo MM.   +17 more
europepmc   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

Petasin at the Membrane: Fine-Tuning Lipid Organization and Interfacial Electrostatics in Mast Cell Plasma Membrane Models. [PDF]

Molecules
Yordanova V, Angelova R, Hazarosova R, Nesheva A, Benkova D, Tancheva T, Vasilev I, Veleva R, Doneva D, Momchilova A, Staneva G.   +10 more
europepmc   +1 more source

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source

First report of polymorphisms and genetic characteristics of the <i>prion-like</i> protein gene (<i>PRND</i>) in bats. [PDF]

Front Vet Sci
Choi DI, Jeong MJ, Na EJ, Oem JK, Jeong BH.   +4 more
europepmc   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Giant Magneto‐Optical Effects in Two‐Dimensional Flat‐Band Antiferromagnets

Advanced Science, EarlyView.
RuOCl2${\rm RuOCl}{_2}$, a two‐dimensional antiferromagnet, hosts energy bands with pronounced directional flatness. This study demonstrates that the flat‐band‐induced optical transitions yield strongly anisotropic absorption and a record‐large magneto‐optical Schafer–Hubert effect, alongside exceptional linear dichroism exceeding 50%.
Ping Yang, Wanxiang Feng, Siyuan Liu, Shan Guan, Liwei Wen, Wei Jiang, Gui‐Bin Liu, Yugui Yao   +7 more
wiley   +1 more source

Circadian rhythm disruption aggravates high-fat diet-induced NAFLD through gut microbiota alterations in mice. [PDF]

Front Microbiol
Sun M, Dong J, Su M, Liu H, Sun Q, Lin K, Yu R, Yang H, Lin J, Chen J, Shen J, Ye H.   +11 more
europepmc   +1 more source

Electrocatalytic CO2 Reduction over Sn‐Cu Bimetallic Catalysts Synthesized via an Amalgamated Lithium Metal Method

Advanced Science, EarlyView.
An amalgamated lithium metal method enables systematic control of Sn–Cu active‐site dimensions from isolated atoms to nanocrystallites. Increasing the metal loading shifts CO2 electroreduction selectivity from acetaldehyde on highly dispersed Sn–Cu sites to formate on Sn‐rich crystallites, revealing how bimetallic dispersion and local coordination ...
Minghao Xie, Shichen Guo, Jianxin Wang, Haozhe Zhang, Xun Zhan, Lauren Valentino, Di‐Jia Liu   +6 more
wiley   +1 more source

Altered GABA_B receptor sensitivity in heavy drinkers indexed using a TMS-based biomarker: a randomized controlled experimental medicine trial. [PDF]

Transl Psychiatry
Montemitro C, Donahue D, Costumati A, Maruottolo F, Terezza S, Sjoberg C, Perini I, Roman M, Kugelberg FC, Heilig M.   +9 more
europepmc   +1 more source