Results 91 to 100 of about 2,591,141 (428)

Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study [PDF]

, 2015
Objectives The interleukin-6 receptor (IL-6R) blocker tocilizumab (TCZ) reduces inflammatory disease activity in rheumatoid arthritis (RA) but elevates lipid concentrations in some patients.
Bathon, Joan M., Beaulieu, Andre D., Carlson, Timothy H., Codding, Christine E., Delles, Christian, Giles, Jon T., Lee, Janet S., McInnes, Iain B., Salmon, Jane E., Sattar, Naveed, Thompson, Liz   +10 more
core   +1 more source

The LDL receptor gene: a mosaic of exons shared with different proteins.

Science, 1985
The multifunctional nature of coated pit receptors predicts that these proteins will contain multiple domains. To establish the genetic basis for these domains (LDL) receptor.
T. Südhof, J. Goldstein, Michael S. Brown, D. Russell   +3 more
semanticscholar   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

Sex differences in body composition in youth with type 1 diabetes and its predictive value in cardiovascular disease risk assessment

Diabetes/Metabolism Research and Reviews, Volume 39, Issue 1, January 2023., 2023
Abstract Background Women with type 1 diabetes (T1D) are more susceptible than men to cardiovascular disease (CVD). Signs of increased risk may already appear among adolescent girls. Objectives We explored the contribution of body composition to the development of CVD risk factors among youth with T1D.
Avivit Brener, Sandy Hamama, Hagar Interator, Asaf Ben Simon, Irina Laurian, Anna Dorfman, Efrat Chorna, Michal Yackobovitch‐Gavan, Asaf Oren, Ori Eyal, Yael Lebenthal   +10 more
wiley   +1 more source

PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment

Journal of Lipid Research, 2013
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the LDL receptor (LDLR) at the cell surface and reroutes the internalized LDLR to intracellular degradation.
Kristian Tveten, Thea Bismo Str⊘m, Knut Erik Berge, Trond P. Leren   +3 more
doaj  

Vector Space Morphology with Linear Discriminative Learning [PDF]

arXiv, 2021
This paper presents three case studies of modeling aspects of lexical processing with Linear Discriminative Learning (LDL), the computational engine of the Discriminative Lexicon model (Baayen et al., 2019). With numeric representations of word forms and meanings, LDL learns to map one vector space onto the other, without being informed about any ...
arxiv  

Effect of probucol on LDL oxidation and atherosclerosis in LDL receptor-deficient mice [PDF]

Journal of Lipid Research, 1998
Probucol is a powerful inhibitor of atherosclerosis in a number of animal models. However, it is unknown whether this is due to the strong antioxidant protection of low density lipoprotein (LDL), to antioxidant effects in the artery wall, or to cellular effects not shared by other antioxidants. To investigate whether murine models are suitable to study
Bird, David A, Tangirala, Rajendra K, Fruebis, Joachim, Steinberg, Daniel, Witztum, Joseph L, Palinski, Wulf   +5 more
openaire   +5 more sources

Towards Genetic Prediction of Coronary Heart Disease in Familial Hypercholesterolemia [PDF]

, 2009
Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipid metabolism caused by mutations in the gene coding for the low-density lipoprotein (LDL) receptor.
Net, J.B. (Jeroen) van der
core   +1 more source

Competitive uptake of porphyrin and LDL via the LDL receptor in glioma cell lines: flow cytometric analysis [PDF]

, 2001
We examined the simultaneous uptake of porphyrin and (LDL) by four established cell lines of glioma and normal ®broblastsusing ¯ow cytometry (FCM). The results indicated porphyrin and LDL showed competitive conjugation with the LDL receptor.These results
Matsumura Akira, Nakai Kei, Nakajima Susumu, Nose Tadao, Sakata Isao, Shibata Yasushi, Yamamoto Tetsuya, Yoshida Fumiyo, 柴田 靖   +8 more
core   +1 more source

Macrophage HM13/SPP Enhances Foamy Macrophage Formation and Atherogenesis

Advanced Science, EarlyView.
Previous research suggests that AIP may prevent atherogenic foamy macrophage formation. This study reveals that AIP, via its chaperone interaction with AHR, inhibits p38‐c‐JUN‐mediated transactivation of HM13, which encodes the ERAD protease HM13/SPP. HM13/SPP promotes foamy macrophage formation in addition to atherogenesis and plaque foamy macrophage ...
Yu Cao, Qirong Xie, Qiang Zheng, Jingping Zhang, Mengyu Yao, Zhongyong Du, Lujun Zhang, Tianyang Hu, Yunli Zhao, Jianlin Du, Yongyong Li, Yuxing Feng, ND Melgiri, Xiaodong Zhao, Rongzhong Huang, Yang Sun   +15 more
wiley   +1 more source