Results 91 to 100 of about 2,605,698 (332)

Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice

Journal of Lipid Research, 2011
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver disease.
S. Subramanian, L. Goodspeed, Shari Wang, Jinkyu Kim, L. Zeng, G. Ioannou, W. Haigh, M. Yeh, K. Kowdley, K. O’Brien, S. Pennathur, A. Chait   +11 more
semanticscholar   +1 more source

Generation of Intracellular Signals by Low Density Lipoprotein Is Independent of the Classical LDL Receptor [PDF]

, 2017
Low density lipoprotein cholesterol (LDL) and apolipoprotein B-100 (1 to 15 μg/mL) had no significant influence on the inositol-1,4,5-trisphosphate (InsPa) formation in vascular smooth muscle cells and fibroblasts. Low density lipoprotein cholesterol (15
Locher, Rudolf, Sachinidis, Agapios, Vetter, Wilhelm   +2 more
core  

Rapid fluorometric assay of LDL receptor activity by DiI-labeled LDL.

Journal of Lipid Research, 1993
DiI-LDL (3,3'-dioctadecylindocarbocyanine-low density lipoprotein) has been extensively used in morphological and microscopic studies of receptor-mediated metabolism of LDL in many cell lines.
ZF Stephan, EC Yurachek
doaj  

Label Distribution Learning [PDF]

arXiv, 2014
Although multi-label learning can deal with many problems with label ambiguity, it does not fit some real applications well where the overall distribution of the importance of the labels matters. This paper proposes a novel learning paradigm named \emph{label distribution learning} (LDL) for such kind of applications.
arxiv  

Interleukin-6 blockade raises LDL via reduced catabolism rather than via increased synthesis: a cytokine-specific mechanism for cholesterol changes in rheumatoid arthritis [PDF]

, 2017
Objectives Patients with rheumatoid arthritis (RA) have reduced serum low-density lipoprotein cholesterol (LDL-c), which increases following therapeutic IL-6 blockade. We aimed to define the metabolic pathways underlying these lipid changes.
Caslake, Muriel, McCarey, David, McInnes, Iain, Packard, Chris J., Porter, Duncan, Robertson, Jamie, Sattar, Naveed   +6 more
core   +1 more source

Reducing saturated fat intake is associated with increased levels of LDL receptors on mononuclear cells in healthy men and women

Journal of Lipid Research, 1997
Studies with animal models suggest that saturated fatty acids raise low density lipoprotein (LDL)-cholesterol levels by reducing LDL receptor-mediated clearance. To examine this directly in humans, we studied the effects of lowering dietary saturated fat
V A Mustad, T D Etherton, A D Cooper, A M Mastro, T A Pearson, S S Jonnalagadda, P M Kris-Etherton   +6 more
doaj  

The giant low-density lipoproteins (LDL) accumulation in the multi-layer artery wall model [PDF]

arXiv, 2014
The mathematical, four-layer model of the LDL transport across the arterial wall including the sensitivity of the transport coefficients to the wall shear stress (WSS) is studied. In that model the advection-diffusion equations in porous media are used to determine the LDL concentration profiles in each layer of the arterial wall.
arxiv  

Low density lipoprotein and liposome mediated uptake and cytotoxic effect of N4-octadecyl-1-β-D-arabinofuranosylcytosine in Daudi lymphoma cells [PDF]

, 1999
Low density lipoprotein (LDL) receptor-mediated uptake and cytotoxic effects of N4-octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC) were studied in Daudi lymphoma cells.
BA Allison, CF Yen, CF Yen, DH Horber, DH Horber, DH Horber, F Jasanada, F Rinninger, Herbert Schott, I Abe, IE Morrison, J Swanson, JL Goldstein, JL Goldstein, KM Wasan, M MacCoss, PCN Rensen, RA Firestone, RA Schwendener, RL Juliano, S Vitols, SKM Koller-Lucae, SKM Koller-Lucae, TJ van Berkel, V Viallard, W Rubas, WR Vogler, ZF Stephan   +27 more
core   +2 more sources

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. [PDF]

, 2014
Low-grade systemic inflammation is often associated with metabolic syndrome, which plays a critical role in the development of the obesity-associated inflammatory diseases, including insulin resistance and atherosclerosis.
DeFranco, Anthony L, Dicorleto, Paul E, Febbraio, Maria, Fox, Paul L, Harding, Clifford V, Hazen, Stanley L, Hise, Amy G, Hu, Bingqing, Li, Xiaoxia, Morton, Richard E, Nagy, Laura E, Ransohoff, Richard M, Roychowdhury, Sanjoy, Schmitt, David, Smith, Jonathan D, Wang, Jian-an, Xiao, Nengming, Yu, Minjia, Zhao, Junjie, Zhou, Hao   +19 more
core   +2 more sources

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S]

Journal of Lipid Research, 2011
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We have identified a fragment antigen-binding (Fab) 1D05 which binds PCSK9 with nanomolar affinity.
Y. Ni, S. Di Marco, J. Condra, L. Peterson, Weirong Wang, Fubao Wang, S. Pandit, Holly A. Hammond, R. Rosa, R. Cummings, Dana D. Wood, Xiaomei Liu, M. Bottomley, Xun Shen, R. Cubbon, Sheng-ping Wang, D. Johns, C. Volpari, Lora Hamuro, J. Chin, Lingyi Huang, J. Zhao, Salvatore Vitelli, Peter Haytko, D. Wisniewski, L. Mitnaul, C. Sparrow, B. Hubbard, A. Carfi, A. Sitlani   +29 more
semanticscholar   +1 more source