Results 261 to 270 of about 230,793 (312)

Hematopoietic Sphingosine 1-Phosphate Lyase Deficiency Decreases Atherosclerotic Lesion Development in LDL-Receptor Deficient Mice

, 2013
Martine Bot, Paul P. Van Veldhoven, Saskia C.A. de Jager, Jason L. Johnson, Niels Nijstad, Peter J. van Santbrink, Marijke M. Westra, Gerd Van der Hoeven, Marion J. Gijbels, Carsten Müller‐Tidow, Georg Varga, Uwe J.F. Tietge, Johan Kuiper, Theo J.C. van Berkel, Jerzy–Roch Nofer, Ilze Bot, Erik A.L. Biessen   +16 more
openalex   +2 more sources

LDL, LDL receptors, and PCSK9 as modulators of the risk for type 2 diabetes: a focus on white adipose tissue

, 2020
May Faraj
openalex   +1 more source

Changes in soluble LDL receptor and lipoprotein fractions in response to diet in the DIETFITS weight loss study. [PDF]

J Lipid Res
Krauss RM, Fisher LM, King SM, Gardner CD.   +3 more
europepmc   +1 more source

Oat β‐Glucan and Galactooligosaccharides Influence Gallstone Formation by Modulating the Gut Microbiota, Particularly Desulfovibrionales

iMetaMed, EarlyView.
Oat β‐glucan and galactooligosaccharides influence the formation of gallstones by modulating the gut microbiota, particularly the abundance of Desulfovibrionales. The primary mechanism involves metabolic byproducts associated with Desulfovibrionales inhibiting hepatic bile acid synthesis via both the hepatic FXR–SHP and intestinal FXR–FGF15 signaling ...
Liang Tian, Yanyan Lin, Ping Yue, Long Gao, Leiqing Wang, Chongfei Huang, Jinyu Zhao, Ningzu Jiang, Jiahui xi, Haidong Ma, Zhen Liu, Ruyang Zhong, Wenkang Fu, Ningning Mi, Mingzhen Bai, Bodong Zhang, Lunzhi Dai, Jiang Li, Hu Chen, Jinqiu Yuan, Wenbo Meng   +20 more
wiley   +1 more source

Inhibition of a novel Dickkopf-1-LDL receptor-related proteins 5 and 6 axis prevents diabetic cardiomyopathy in mice. [PDF]

Eur Heart J
Ma E, Wo D, Chen J, Yan H, Zhou X, He J, Wu C, Wang Q, Zuo C, Li X, Li L, Meng Q, Zheng L, Peng L, Chen L, Peng J, Ren DN, Zhu W.   +17 more
europepmc   +1 more source

Metabolic Signatures and Diagnostic Prediction Models for Coronary Artery Disease and Type 2 Diabetes Mellitus: Insights From an Exploratory Study

iNew Medicine, EarlyView.
Metabolomic & lipidomic analysis reveals metabolic overlap between CAD & T2DM, highlighting 7 key metabolites as potential biomarkers. A predictive model based on these achieves high accuracy, potentially advancing precision medicine & metabolic insights.
Zhihua Wang, Meiming Su, Ying Li, Yapei Li, Shuo Chen, Ting Peng, Hans Strijdom, Jiangang Wang, Jianping Weng, Suowen Xu   +9 more
wiley   +1 more source

LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments. [PDF]

Nat Commun
Tang W, Luan Y, Yuan Q, Li A, Chen S, Menacherry S, Young L, Wu D.   +7 more
europepmc   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

Schisandrin A in Schisandra chinensis Upregulates the LDL Receptor by Inhibiting PCSK9 Protein Stabilization in Steatotic Model. [PDF]

J Microbiol Biotechnol
Kim HJ, Park SK, Park SH, Lee YG, Park JH, Hwang JT, Chung MY.   +6 more
europepmc   +1 more source