Results 261 to 270 of about 2,612,734 (405)

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

The role of proprotein convertase subtilisin/kexin 9 (PCSK9) in macrophage activation: a focus on its LDL receptor-independent mechanisms. [PDF]

Front Cardiovasc Med
Katsuki S, Jha PK, Aikawa E, Aikawa M.
europepmc   +1 more source

Pregnane X Receptor Mediates Atherosclerosis Induced by Dicyclohexyl Phthalate in LDL Receptor-Deficient Mice. [PDF]

Cells, 2022
Liu J, Hernandez R, Li X, Meng Z, Chen H, Zhou C.   +5 more
europepmc   +1 more source

LDL binding sites on platelets differ from the "classical" receptor of nucleated cells.

, 1992
J. Pedreño, Conxita de Castellarnau, C Cullaré, José Luis Sánchez, J.A. Gómez-Gerique, Jordi Ordóñez‐Llanos, Francesc González‐Sastre   +6 more
openalex   +1 more source

Characterization of a Splice-Site Mutation in the Gene for the LDL Receptor Associated With an Unpredictably Severe Clinical Phenotype in English Patients With Heterozygous FH [PDF]

, 1995
Xi-Ming Sun, D. Patel, Deepak Bhatnagar, Brian L. Knight, Anne K. Soutar   +4 more
openalex   +1 more source

Temporal response patterns of human gut microbiota to dietary fiber

iMeta, EarlyView.
In this study, 19 overweight participants, with or without type 2 diabetes mellitus, underwent 14 days of normal‐diet observation followed by 14 days of dietary fiber intervention. Fecal samples and continuous glucose monitoring data were collected daily throughout the 28‐day period.
Xiaotong Lin, Chaoxun Wang, Biao Liu, Yin Zhu, Rui Zhai, Chenhong Zhang   +5 more
wiley   +1 more source

Corrigendum to: Protein kinase C activation stabilizes LDL receptor mRNA via the JNK pathway in HepG2 cells [Journal of Lipid Research 50/3 (2008) 386-397]. [PDF]

J Lipid Res
Vargas NB, Brewer BY, Rogers TB, Wilson GM.   +3 more
europepmc   +1 more source

Alteration in Rab11-mediated endocytic trafficking of LDL receptor contributes to angiotensin II-induced cholesterol accumulation and injury in podocytes. [PDF]

Cell Prolif, 2022
Hu J, Zhu Z, Chen Z, Yang Q, Liang W, Ding G.   +5 more
europepmc   +1 more source

Angiotensin II–Modified LDL Is Taken Up by Macrophages Via the Scavenger Receptor, Leading to Cellular Cholesterol Accumulation [PDF]

, 1996
Shlomo Keidar, Marielle Kaplan, Michael Aviram   +2 more
openalex   +1 more source

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii

Journal of Applied Toxicology, EarlyView.
ABSTRACT Serendipity Berry Sweet Protein (sweelin) is a novel hyper‐sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI‐CPD) to improve the stability and sensory profile of the protein found in serendipity berry (Dioscoreophyllum cumminsii).
Yael Lifshitz, Shira Paz, Rotem Saban, Inbar Zuker, Hagay Shmuely, Katy Gorshkov, Jwar Meetro, Shahrzad Tafazoli, Trung Vo, Gabriela Amiram, Carmit Shani Levi, Uri Lesmes, Ilan Samish   +12 more
wiley   +1 more source