Results 331 to 340 of about 2,612,734 (405)

Photoperiod‐Dependent Effects of Phenolic‐Enriched Fruit Extracts on Postprandial Triacylglyceride Levels and Acute Inflammatory Responses in F344 Rats

Molecular Nutrition &Food Research, EarlyView.
This study investigates the photoperiod‐dependent effects of eight phenolic‐rich fruit extracts on postprandial blood triacylglyceride (TAG) levels and serum inflammatory markers in F344 rats, following an oral lipid tolerance test (OLTT) and a lipopolysaccharide (LPS)‐induced inflammatory challenge. Results showed that cherry and plum extracts reduced
Francesca Manocchio, Diego Morales, Èlia Navarro‐Masip, Gerard Aragones, Cristina Torres‐Fuentes, Francisca Isabel Bravo, Begoña Muguerza   +6 more
wiley   +1 more source

Increased Nitrate Intake From Beetroot Juice Over 4 Weeks Changes the Composition of the Oral, But Not the Intestinal Microbiome

Molecular Nutrition &Food Research, EarlyView.
This randomized, double‐blind, and placebo‐controlled crossover study investigated the effects of an increased intake of inorganic nitrate from beetroot juice over 4 weeks on the oral and intestinal microbial communities in older adults with treated high blood pressure.
Rebeka Fejes, Joana Séneca, Petra Pjevac, Martin Lutnik, Stefan Weisshaar, Nina Pilat, Romy Steiner, Karl‐Heinz Wagner, Richard J. Woodman, Catherine P. Bondonno, Jonathan M. Hodgson, David Berry, Michael Wolzt, Oliver Neubauer   +13 more
wiley   +1 more source

Beyond weight loss: exploring bile acid modulations after bariatric surgery and their impact on type 2 diabetes across 5 years

Obesity, EarlyView.
Abstract Objective This study aimed to explore the dynamic role of bile acids (BAs) in metabolic improvements following bariatric surgery, specifically comparing the effects of silastic ring laparoscopic Roux‐en‐Y gastric bypass (SR‐LRYGB) and laparoscopic sleeve gastrectomy (LSG) on BA composition and clinical parameters over a 5‐year period.
John Zhiyong Yang, Michelle Li, Weiyu Zhou, Reza Nemati, Xiaodong Jin, Lindsay D. Plank, Rinki Murphy, Jun Lu   +7 more
wiley   +1 more source

Metabolic clearance rate of insulin across the glucose tolerance spectrum by race and ethnicity in youth with obesity

Obesity, EarlyView.
Abstract Objective Despite β‐cell failure in youth with dysglycemia (i.e., impaired glucose tolerance [IGT] and type 2 diabetes), fasting insulin (FI) concentrations are elevated. Herein, we examined the following: 1) metabolic clearance rate of insulin (MCRI) in youth with obesity and normal glucose tolerance (NGT) versus those with IGT versus those ...
Wonhee Cho, Fida Bacha, Hala Tfayli, SoJung Lee, Sara F. Michaliszyn, Joon Young Kim, Silva Arslanian   +6 more
wiley   +1 more source

LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice [PDF]

, 2018
Jeong, Lak Shin, Jeong, Se-Jin, Kim, Gyudong, Oh, Goo Taeg, Park, Jong-Gil, Yu, Jinha   +5 more
core   +1 more source

Nutritional priorities to support GLP‐1 therapy for obesity: A joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society

Obesity, EarlyView.
Abstract Background Glucagon‐like peptide 1 receptor agonists and combination medications (hereafter collectively referred to as GLP‐1s) are shifting the treatment landscape for obesity. However, real‐world challenges and limited clinician and public knowledge on nutritional and lifestyle interventions can limit GLP‐1 efficacy, equitable results, and ...
Dariush Mozaffarian, Monica Agarwal, Monica Aggarwal, Lydia Alexander, Caroline M. Apovian, Shagun Bindlish, Jonathan Bonnet, W. Scott Butsch, Sandra Christensen, Eugenia Gianos, Mahima Gulati, Alka Gupta, Debbie Horn, Ryan M. Kane, Jasdeep Saluja, Deepa Sannidhi, Fatima Cody Stanford, Emily A. Callahan   +17 more
wiley   +1 more source

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Cholesterol in LDL receptor recycling and degradation

Clinica Chimica Acta, 2020
The SREBP2/LDLR pathway is sensitive to cholesterol content in the endoplasmic reticulum (ER), while membrane low-density lipoprotein receptor (LDLR) is influenced by sterol response element binding protein 2 (SREBP2), pro-protein convertase subtilisin/kexin type 9 (PCSK9) and inducible degrader of LDLR (IDOL).
Hui-xian Yang, Min Zhang, Shi-yin Long, Qin-hui Tuo, Ying Tian, Jian-xiong Chen, Cai-ping Zhang, Duan-fang Liao   +7 more
openaire   +4 more sources

Lowering LDL cholesterol, but not raising LDL receptor activity, by ezetimibe [PDF]

Journal of Clinical Lipidology, 2013
Ezetimibe, an inhibitor of intestinal cholesterol absorption, is effective in lowering serum low-density lipoprotein (LDL) cholesterol with or without coadministration of statin. Ezetimibe-plus-statin therapy enhances LDL receptor activity, but it is still unclear whether ezetimibe alone enhances LDL receptor activity, resulting in LDL cholesterol ...
Mitsunobu Kawamura, Hiroshi Hayashi
openaire   +2 more sources

LDL Receptor's β-Propeller Displaces LDL [PDF]

Science, 2002
The low density lipoprotein receptor (LDLR) binds to lipoprotein extracellularly and releases it in the endosome. In his Perspective, Innerarity discusses new structural work (Rudenkoet al.) that shows that an interdomain interaction that occurs at low pH likely displaces ligand from the receptor in the endosome.
openaire   +1 more source

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system.

Annual Review of Cell Biology, 1985
PATHWAYS OF RECEPTOR-MEDIATED ENDOCYTOSIS 3 Entry Into Coated Pits 3 Intracellular Routes ...
J. Goldstein, M. Brown, R. G. Anderson, D. Russell, W. Schneider   +4 more
semanticscholar   +1 more source