Results 351 to 360 of about 2,612,734 (405)

Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.

Science, 1991
Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor.
C. Wilson, M. Wardell, K. Weisgraber, R. Mahley, D. Agard   +4 more
semanticscholar   +1 more source

Diverse roles for the LDL receptor family

Trends in Endocrinology & Metabolism, 2002
The low-density lipoprotein (LDL) receptor family consists of several related scavenger receptors that not only function as important cargo transporters, but also inform the cell of changes in its environment by mediating signaling responses. The LDL receptor was the first family member to be characterized and its function seems to be restricted to ...
Steven L. Gonias, W. Scott Argraves, Dudley K. Strickland   +2 more
openaire   +3 more sources

LDL Receptor‐Related Proteins in Neurodevelopment

Traffic, 2003
Low‐density lipoprotein receptor‐related proteins (LRPs) are evolutionarily ancient cell‐surface receptors with diverse biological functions. All are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment.
Joachim Herz, Petra May
openaire   +3 more sources

Regulation of LDL Receptors in vivo

1984
The information reviewed here indicates that LDL receptor activity in vivo is regulated in normal animals and probably in normal humans. Furthermore, LDL receptor activity is also regulated in patients with heterozygous Familial Hypercholesterolemia. Our experiments in patients with this disease indicate that one can exploit the normal regulation of ...
openaire   +3 more sources

5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes.

Science, 1990
Direct genomic sequencing revealed that cytosine residues known to have undergone a germ-line mutation in the low density lipoprotein receptor gene or somatic mutations in the p53 tumor suppressor gene were methylated in all normal human tissues analyzed.
William M. Rideout, G. Coetzee, A. Olumi, Peter A. Jones   +3 more
semanticscholar   +1 more source

Scavenger Receptors, Oxidized LDL, and Atherosclerosis

Annals of the New York Academy of Sciences, 2001
Abstract: Oxidized LDL (OxLDL) competes with oxidatively damaged and apoptotic cells for binding to mouse peritoneal macrophages, implying the presence of one or more common domains. However, the nature of the ligands involved has not been determined.
Joseph L. Witztum, Oswald Quehenberger, Peter X. Shaw, Wulf Palinski, David A. Bird, Agnès Boullier, Mi-Kyung Chang, Daniel Steinberg, Kristin Gillotte-Taylor, Sohvi Hörkkö, Valeska Terpstra, Edward A. Dennis, Peter Friedman   +12 more
openaire   +3 more sources

Differences in Receptor Binding of LDL Subfractions

Arteriosclerosis, Thrombosis, and Vascular Biology, 1996
AbstractDifferences in low density lipoprotein (LDL) receptor-binding affinity among LDL particles of different size were examined in competitive binding assays in human skin fibroblasts and LDL (d=1.020 to 1.050 g/mL) from subjects with a predominance of large (≥272 Å), medium (259 to 271 Å), and small (≤257 Å) LDL. Among 57 normolipidemic subjects
Ronald M. Krauss, Hannia Campos, Thomas L. Innerarity, Kay S. Arnold, Maureen E. Balestra   +4 more
openaire   +3 more sources

Activation of EGF receptor by oxidized LDL

The FASEB Journal, 1998
Oxidized low density lipoproteins (oxLDL) are thought to play a major role in atherosclerosis. OxLDL exhibit a wide variety of biological effects resulting from their ability to interfere with intracellular signaling. The cellular targets and primary signaling events of oxLDL are unknown.
Jean Vandaele, Günther Jürgens, Anne Nègre-Salvayre, Olivier Meilhac, Isabelle Suc, Robert Salvayre, Isabelle Lajoie-Mazenc   +6 more
openaire   +2 more sources

Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.

Antioxidants and Redox Signaling, 2011
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) has been identified as a major receptor for oxidized low-density lipoprotein (ox-LDL) in endothelial cells, monocytes, platelets, cardiomyocytes, and vascular smooth muscle cells.
Jingjun Lu, Sona Mitra, Xianwei Wang, M. Khaidakov, J. Mehta   +4 more
semanticscholar   +1 more source

The Role of the LDL Receptor in Lipoprotein Metabolism

1987
The discovery of the LDL receptor in cultured mammalian cells by Goldstein and Brown in 1973 was followed by a rapid increase in our understanding of cellular and total body cholesterol metabolism1. The LDL receptor is the starting point for an intracellular pathway which is of fundamental importance in regulating cellular cholesterol metabolism ...
David W. Bilheimer, Scott M. Grundy
openaire   +3 more sources