Results 51 to 60 of about 647,688 (191)

Miguel Cordero del Campillo. Chronicler and Historian of Education

open access: yesHistoria de la Educación, 2018
Miguel Cordero del Campillo is Professor Emeritus of Parasitology, former president and the official chronicler of his alma mater the University of Leon (Spain).
Raquel POY CASTRO
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Boletín oficial de la provincia de León: 1979 abril 2 [PDF]

open access: yes, 1979
Copia digital. Valladolid : Junta de Castilla y León.
León (Provincia). Diputación Provincial
core  

Boletín oficial de la provincia de León: 1975 noviembre 21 [PDF]

open access: yes, 1975
Copia digital. Valladolid : Junta de Castilla y León.
León (Provincia). Diputación Provincial
core   +1 more source

Los títulos de los reyes de León en los documentos medievales como reflejo de la continuidad del reino visigodo de Toledo

open access: yesEstudios de Historia de España, 2016
Based on the notion posed by S. Teillet that the Visigothic Kingdom of Toledo in its latter stages came to be fully identified with Hispania, as well as on the fact that there was real and evident continuity between the Visigothic Kingdom and the Kingdom
Julia Montenegro, Arcadio del Castillo
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Leones y zorros: Poder y gobierno en las fábulas medievales hebreas

open access: yesRevista de Paz y Conflictos, 2009
Este artículo ofrece un estudio de las relaciones entre el león y el zorro como metáforas de las conexiones en la arena política. Presentaremos un análisis de las relaciones entre gobernadores (león y zorro) y sus súbditos en la filosofía antigua y en la
Revital Refael-Vivante
doaj  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

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