Results 51 to 60 of about 1,178,638 (233)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
La inscripción de Santa María de Castrelos. Un testimonio epigráfico de la O.M. de San Juan
Cuadernos de Estudios Gallegos, 2006 Se estudia la inscripción del año 1216 de la iglesia de Santa María de Castrelos (Vigo, Pontevedra, España), vinculada a la Orden Hospitalaria de San Juan de Malta; se analizan sus aspectos epigráficos, cronológicos e históricos.
Pablo S. Otero Piñeyro Maseda
doaj +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
An Introduction to Algebraic Geometry codes
, 2015 We present an introduction to the theory of algebraic geometry codes. Starting from evaluation codes and codes from order and weight functions, special attention is given to one-point codes and, in particular, to the family of Castle ...
Munuera, Carlos, Olaya-León, Wilson
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FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Relativistic-dft study of the electronic structure, bonding and energetic of the [ref8]־ and [uf8]2- ions [PDF]
, 2013 Indexación: ScieloABSTRACT In this study we evaluated the importance of the relativistic effects (scalar and spin-orbit) on the description of the electronic structure, bonding and the energetic of the [ReF8]- and [UF8]2- ions.
Rabanal-León, Walter A.
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
Un protector laminado de brazo (manica) procedente del campamento de la legio VII Gemina en León
Archivo Español de Arqueología, 2008 Las excavaciones arqueológicas desarrolladas durante 1998 en un solar de la calle Santa Marina, inmediato a la cara interna de la muralla bajoimperial de León, revelaron un gran edificio perteneciente al campamento de la legio VII gemina, que ha sido ...
Joaquín Aurrecoechea +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
On the second moment of the number of crossings by a stationary Gaussian process
, 2006 Cram\'{e}r and Leadbetter introduced in 1967 the sufficient condition \[\frac{r''(s)-r''(0)}{s}\in L^1([0,\delta],dx),\qquad \delta>0,\] to have a finite variance of the number of zeros of a centered stationary Gaussian process with twice differentiable ...
Kratz, Marie F., León, José R.
core +3 more sources