Results 31 to 40 of about 156,291 (204)

Tablas de nuevos maestros castellanos anteriormente atribuidas al maestro de Palanquinos (h. 1480-1500)

open access: yesArchivo Español de Arte, 2019
El Maestro de Palanquinos es un pintor anónimo del área de León de finales del siglo XV a quien se le han atribuido numerosas tablas y conjuntos. Con un estilo hispano-flamenco y trazo particular, gozó de cierta importancia en ámbito diocesano.
Marc Ballesté Escorihuela
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

La inscripción de Santa María de Castrelos. Un testimonio epigráfico de la O.M. de San Juan

open access: yesCuadernos de Estudios Gallegos, 2006
Se estudia la inscripción del año 1216 de la iglesia de Santa María de Castrelos (Vigo, Pontevedra, España), vinculada a la Orden Hospitalaria de San Juan de Malta; se analizan sus aspectos epigráficos, cronológicos e históricos.
Pablo S. Otero Piñeyro Maseda
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Un protector laminado de brazo (manica) procedente del campamento de la legio VII Gemina en León

open access: yesArchivo Español de Arqueología, 2008
Las excavaciones arqueológicas desarrolladas durante 1998 en un solar de la calle Santa Marina, inmediato a la cara interna de la muralla bajoimperial de León, revelaron un gran edificio perteneciente al campamento de la legio VII gemina, que ha sido ...
Joaquín Aurrecoechea   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Miguel Cordero del Campillo. Chronicler and Historian of Education

open access: yesHistoria de la Educación, 2018
Miguel Cordero del Campillo is Professor Emeritus of Parasitology, former president and the official chronicler of his alma mater the University of Leon (Spain).
Raquel POY CASTRO
doaj   +1 more source

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