Results 31 to 40 of about 156,291 (204)
El Maestro de Palanquinos es un pintor anónimo del área de León de finales del siglo XV a quien se le han atribuido numerosas tablas y conjuntos. Con un estilo hispano-flamenco y trazo particular, gozó de cierta importancia en ámbito diocesano.
Marc Ballesté Escorihuela
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Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
La inscripción de Santa María de Castrelos. Un testimonio epigráfico de la O.M. de San Juan
Se estudia la inscripción del año 1216 de la iglesia de Santa María de Castrelos (Vigo, Pontevedra, España), vinculada a la Orden Hospitalaria de San Juan de Malta; se analizan sus aspectos epigráficos, cronológicos e históricos.
Pablo S. Otero Piñeyro Maseda
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This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
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Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
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Un protector laminado de brazo (manica) procedente del campamento de la legio VII Gemina en León
Las excavaciones arqueológicas desarrolladas durante 1998 en un solar de la calle Santa Marina, inmediato a la cara interna de la muralla bajoimperial de León, revelaron un gran edificio perteneciente al campamento de la legio VII gemina, que ha sido ...
Joaquín Aurrecoechea +3 more
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Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
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LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
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Miguel Cordero del Campillo. Chronicler and Historian of Education
Miguel Cordero del Campillo is Professor Emeritus of Parasitology, former president and the official chronicler of his alma mater the University of Leon (Spain).
Raquel POY CASTRO
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