Results 111 to 120 of about 15,018,893 (299)
Leads leading leaflets to leak [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2018 Jihoon, Kim, Jae Won, Lee
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Law Professor, Alumna Lead City Year Board [PDF]
, 2015 Professor Andy Horwitz and Stephanie Federico ‘03 co-chair advisory board of City Year Providence, aiming to dramatically cut dropout ...
Bowden, Michael M.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Rep. Roy Blunt: Unfit to Lead [PDF]
, 2006 Rep. Roy Blunt (R-Mo.), who is vying to be House majority leader, is unfit for leadership because he represents more of the same corrupting, big-money politics that the American public has become disgusted with and that many reformers in Congress are ...
Conor Kenny, Taylor Lincoln
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
CSID Journal of Infrastructure DevelopmentAs climate change continues to exacerbate weather patterns, flood susceptibility has become an increasingly pressing global concern. The susceptibility to floods is influenced by many contextual factors; as such, characterizing coastal neighbourhoods for
Saudat O. Ajijola +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Wheat straws-derived hierarchical porous carbon as electrode material for supercapacitor
Discover ElectronicsHierarchical porous carbon materials hold great potential in electrochemical energy storage, yet their efficient fabrication still faces numerous challenges. Herein, we successfully prepared hierarchical porous carbon materials with high specific surface
Zhenjuan Zang +5 more
doaj +1 more source