Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Radha D’Souza, Interstate Disputes over Krishna Waters: Law, Science and Imperialism (New Delhi: Orient Longman, 2006) - Book Review [PDF]
Reviewed by Usha Ramanathan, LEAD Journal
doaj
ECG and Anatomical Features in Patients of Left Coronary Cusp Ventricular Arrhythmias With R Wave in Lead I. [PDF]
Hara S +10 more
europepmc +1 more source
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
John R. Nolon ed, Compendium of Land Use Laws for Sustainable Development (Cambridge : Cambridge University Press, 2006) - Book Review [PDF]
Reviewed by Roopa Madhav, LEAD Journal
doaj
Lead concentration in follicular fluid of infertile patients with and without endometriosis: a propensity score matching exploratory study. [PDF]
Iavarone I +6 more
europepmc +1 more source
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Exogenous pipecolic acid ameliorates lead-induced phytotoxicity in chili (<i>Capsicum annuum</i> L.) by enhancing antioxidant capacity and physiological homeostasis. [PDF]
Iqbal R +8 more
europepmc +1 more source
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Reconstructing 12-lead ECG from 3-lead ECG using variational autoencoder to improve cardiac disease detection of wearable ECG devices. [PDF]
Guan X +11 more
europepmc +1 more source

