Results 111 to 120 of about 754,901 (303)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Multi-level complexities in technological development: Competing strategies for drug discovery [PDF]

, 2009
Drug development regularly has to deal with complex circumstances on two levels: the local level of pharmacological intervention on specific target proteins, and the systems level of the effects of pharmacological intervention on the organism.
Adam, Matthias
core  

High throughput screening approach to lead discovery

, 2010
A review. A review on high throughput screening (HTS) strategies for lead discovery. Topics covered include: historical background; screening collection enhancement strategies; HTS assays and equipment; hit confirmation and assessment; and successes ...
Zoran Rankovic, Rankovic, Zoran, Craig Jamieson, Jamieson, Craig, Morphy, Richard., Richard Morphy   +5 more
core   +1 more source

Solution-Phase Combinatorial Chemistry in Lead Discovery

CHIMIA, 1997
Solution-phase approaches in combinatorial chemistry complement solid-phase approaches and each can be used to advantage in particular circumstances.
Nick Bailey, Stuart Travers, Richard Storer, Andrew T. Merritt, Duncan B. Judd, Michael C. Hawes, Andrea L. Gore, Anthony W. Dean, Martyn J. Deal, Anthony W.J. Cooper, Stephen P. Watson   +10 more
doaj   +2 more sources

Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily

Frontiers in Pharmacology
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells.
Daniela Digles, Alvaro Ingles-Prieto, Vojtech Dvorak, Tamara A. M. Mocking, Ulrich Goldmann, Andrea Garofoli, Evert J. Homan, Alberto Di Silvio, Lucia Azzollini, Francesca Sassone, Mario Fogazza, Felix Bärenz, Antje Pommereau, Yasmin Zuschlag, Jasper F. Ooms, Jeppe Tranberg-Jensen, Jesper S. Hansen, Josefina Stanka, Hubert J. Sijben, Helena Batoulis, Eckhard Bender, Riccardo Martini, Adriaan P. IJzerman, David B. Sauer, Laura H. Heitman, Vania Manolova, Juergen Reinhardt, Alexander Ehrmann, Philipp Leippe, Gerhard F. Ecker, Kilian V. M. Huber, Thomas Licher, Lia Scarabottolo, Tabea Wiedmer, Giulio Superti-Furga, Giulio Superti-Furga   +35 more
doaj   +1 more source

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

Scientific Reports, 2016
ADAM10 and ADAM17 have been shown to contribute to the acquired drug resistance of HER2-positive breast cancer in response to trastuzumab. The majority of ADAM10 and ADAM17 inhibitor development has been focused on the discovery of compounds that bind ...
Franck Madoux, Daniela Dreymuller, Jean-Phillipe Pettiloud, Radleigh Santos, Christoph Becker-Pauly, Andreas Ludwig, Gregg B. Fields, Thomas Bannister, Timothy P. Spicer, Mare Cudic, Louis D. Scampavia, Dmitriy Minond   +11 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Why is Price Discovery in Credit Default Swap Markets News-Specific?

: We analyse daily lead-lag patterns in US equity and credit default swap (CDS) returns. We first document that equity returns robustly lead CDS returns.
Marsch, I., Wagner, W.B.
core  

Fragment-based lead discovery on G-protein-coupled receptors

, 2013
Introduction: G-protein-coupled receptors (GPCRs) form one of the largest groups of potential targets for novel medications. Low druggability of many GPCR targets and inefficient sampling of chemical space in high-throughput screening expertise however ...
Visegrády, András, Keserű, György Miklós   +1 more
core   +1 more source

A soft-computation hybrid method for search of the antibiotic-resistant gene in Mycobacterium tuberculosis for promising drug target identification and antimycobacterial lead discovery. [PDF]

Bioinform Adv, 2023
Jaiswal N, Kumar A.
europepmc   +1 more source