Results 101 to 110 of about 2,290,510 (294)

Searching for novel carbonic anhydrase inhibitors: from virtual screening to the lab bench [PDF]

, 2013
Carbonic Anhydrases (CAs) are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate both in prokaryotes and eukaryotes.
Cadoni, Roberta, Dallocchio, Roberto, Dessì, Alessandro, Ihm, Simone, Pala, Nicolino, Roggio, Anna Maria, Sechi, Mario, Supuran, Claudiu T., Weber, Rino   +8 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Credit spreads: An empirical analysis on the informational content of stocks, bonds, and CDS.. [PDF]

This paper explores the dynamic relationship between stock market implied credit spreads, CDS spreads, and bond spreads. A general VECM representation is proposed for changes in the three credit spread measures which accounts for zero, one, or two ...
Forte, Santiago, Peña Sánchez de Rivera, Juan Ignacio   +1 more
core  

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. [PDF]

, 2018
Bioactive natural products have evolved to inhibit specific cellular targets and have served as lead molecules for health and agricultural applications for the past century1-3.
Bat-Erdene, Undramaa, Gan, Jianhua, Jacobsen, Steven E, Liu, Qikun, Nguyen, Calvin, Tang, Yi, Yan, Yan, Yuan, Shuguang, Zang, Xin, Zhou, Jiahai   +9 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Microtiter plate-based chemistry and in situ screening: SuFEx-enabled lead discovery of selective AChE inhibitors. [PDF]

J Enzyme Inhib Med Chem, 2023
Tang K, Li HH, Wu C, Zhang SL, Yang JG, Tang W, Qin HL.   +6 more
europepmc   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Preclinical Characterization of SDFZ‐8, a Highly Potent HDAC1 Inhibitor, for Cancer Immunotherapy

MedComm
The histone deacetylases (HDACs) family plays a critical role in tumorigenesis and has been identified as having a significant impact on tumor immunity.
Yi Zhou, Jintong Du, Xue Li, Huajun Zhao, Junxin Xue, Yuchen Liu, Xinying Yang, Jinming Yu, Xuben Hou, Hao Fang   +9 more
doaj   +1 more source

Remission during pregnancy of severe Chronic Hypertension due to 11-ß Hydroxylase Deficiency [PDF]

, 2004
When hypertension is a result of an underlying identifiable abnormality, the latter's early discovery can lead to a timely cure of the hypertension and the prevention of its complications.
Attard, Gerhardt, Cachia, Mario J.
core  

Supersymmetry in the shadow of photini

, 2012
Additional neutral gauge fermions -- "photini" -- arise in string compactifications as superpartners of U(1) gauge fields. Unlike their vector counterparts, the photini can acquire weak-scale masses from soft SUSY breaking and lead to observable ...
A Arvanitaki, A Arvanitaki, A Ibarra, A Melchiorri, AH Chamseddine, B Allanach, B Allanach, B Holdom, C Brust, C Cheung, C Cheung, C Csáki, C Degrande, D Das, G Aad, G Aad, G Aad, G Aad, G Aad, G Aad, G Aad, G Giudice, GF Giudice, GL Kane, J Alwall, J Alwall, J Fan, JF Gunion, Ken Van Tilburg, KR Dienes, LE Ibáñez, LJ Hall, LM Carpenter, M Cicoli, M Goodsell, M Goodsell, Masha Baryakhtar, N Arkani-Hamed, N Craig, N Craig, N Craig, N Ohta, Nathaniel Craig, ND Christensen, P Svrček, R Barbieri, R Barbieri, R Essig, S Abel, S Chatrchyan, S Chatrchyan, S Chatrchyan, S Chatrchyan, S Davidson, S Davidson, S Dimopoulos, S Dubovsky, T Sjöstrand, TJ LeCompte, TJ LeCompte, Y Kats   +60 more
core   +1 more source