Results 81 to 90 of about 754,901 (303)
Most potential natural products for lead discovery.
, 2013 Most potential natural products for lead discovery.
Gu Yuan (182613) +5 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Lead Discovery for Targeting G Protein-coupled Receptors
, 2011 G protein-coupled receptors (GPCRs) control a plethora of key physiological functions in every cell of an organism. GPCRs are therefore involved in many diseases, since altered ligand or receptor levels, and genetic or epigenetic modifications can lead ...
Jacob, Sandra, Siehler Wagner, Sandra
core
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Price Discovery in Canadian Government Bond Futures and Spot Markets [PDF]
In this paper we look at the relative information content of cash and futures prices for Canadian Government bonds. We follow the information-share approaches introduced by Hasbrouck (1995) and Harris et al (1995), applying the techniques in Gonzalo ...
Christopher Chung +2 more
core
Photochemistry in Flow for Drug Discovery
, 2021 S.71-119The discovery of new drug candidates and the development of new lead structures for future active pharmaceutical ingredients are continuous processes, which combine the expertise of many scientific disciplines.
Rehm, Thomas H., Thomas H. Rehm
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2014 The compound NVP-BEZ235 (1) is a potent inhibitor of human phospoinositide-3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) that also showed high inhibitory potency against T. brucei cultures. With an eye towards using 1 as a starting point for
Pollastri, Michael P +10 more
core +1 more source
Streptococcal dTDP-L-rhamnose biosynthesis enzymes:functional characterization and lead compound identification [PDF]
, 2019 Biosynthesis of the nucleotide sugar precursor dTDP-L-rhamnose is critical for the viability and virulence of many human pathogenic bacteria, including Streptococcus pyogenes (Group A Streptococcus; GAS), Streptococcus mutans and Mycobacterium ...
Dorfmueller, Helge C. +33 more
core +1 more source
Targeted Approaches in Natural Product Lead Discovery
CHIMIA, 2006 Natural products still constitute a prolific source of lead compounds for the development of novel drugs. Due to their unmatched structural diversity they represent an indispensable complement to synthetic compound collections and virtual ...
Olivier Potterat
doaj +1 more source