Results 51 to 60 of about 1,521,832 (315)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
The relation between lead exposure and inflammation / endothelial dysfunction
Medicine Science, 2020 Pb exposure is a well-known risk factor for inflammation including vessels. In our study, we aimed to investigate the relationship between Pb levels of exposed workers and the severity of inflammation/endothelial dysfunction.
Lutfiye Tutkun +5 more
doaj +1 more source
Study of some biochemical variables in the blood serum of workers in the service sector exposed to lead [PDF]
مجلة التربية والعلم, 2009 The present study included the effect of lead on some of biochemical variables for (150) worker from non smokers normal male workers who occupationally exposed to lead pollution, through their daily work.
Mona Janger, Hala Alsafar
doaj +1 more source
Lead exposure and child behavior [PDF]
Journal of Safety Research, 1992 OBJECTIVES. Unlike cognitive impairments associated with lead exposure, lead-associated child behavior problems have been difficult to specify, particularly in young children. METHODS. The Child Behavior Checklist (CBCL) and the Center for Epidemiologic Studies Depression Scale were used as the outcome and confounding variables, respectively, of major
W G, Sciarillo +2 more
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Blood lead determinants and the prevalence of neuropsychiatric symptoms in firearm users in Mexico
International Journal of Occupational Medicine and Environmental Health, 2016 Objectives: To identify blood lead predictors and the prevalence of neuropsychiatric symptoms in firearm users of public security in Mexico. Material and Methods: A cross-sectional study was performed on 65 males.
Guadalupe Aguilar Madrid +6 more
doaj +1 more source
Lead Exposure and Prevention Advisory Committee (LEPAC) : 2020 annual report to U.S. Department of Health and Human Services [PDF]
The objective of the Lead Exposure and Prevention Advisory Committee (LEPAC) is to review research andFederal programs and services related to lead poisoning and to identify effective services and best practices for addressing and preventing lead ...
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source