Results 51 to 60 of about 5,205 (129)

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3819-3830, November 2026.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Possible Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS) Presenting in Late Adolescence and Early Adulthood: A Case Series

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT PANDAS‐like syndromes may rarely occur beyond childhood. Although these patients may meet criteria for PANS, recognizing a possible streptococcal‐triggered subgroup remains important for diagnosis, future biomarker discovery, and refinement of disease classification.
Tariq A. Madani, Fahd S. Alsallum, Ola H. Abudaowd, Salman T. Madani   +3 more
wiley   +1 more source

Beyond Connection: Paradoxes of Psychedelic Resonance in Late Modernity

Future Humanities, Volume 4, Issue 2, November 2026.
ABSTRACT This essay explores the enduring suspicion that psychedelic experiences are antithetical to the structural dynamic of modern societies through Hartmut Rosa's concepts of ‘resonance’ and ‘social acceleration’. Rosa's theoretical framework is particularly generative for studying the social meaning of contemporary psychedelia because it enables a
Mateo Sanchez Petrement
wiley   +1 more source

Baseline Clinical Predictors and Toxicological Drivers of In‐Hospital Poisoning Mortality in Resource‐Constrained Emergency Care: A Firth Penalized Regression Analysis

Health Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background Evidence regarding clinical characteristics and determinants of mortality among patients with acute poisoning in agricultural regions of Ethiopia remains limited. This study aimed to evaluate baseline clinical predictors associated with in‐hospital mortality among acutely poisoned patients in a low‐resource tertiary emergency ...
Zewdu Hurisa, Ayalneh Demissie, Nebyu Mekonnen, Birhanu Asefa, Abera Girma, Helen Bekele, Tesfa Gebremeskel   +6 more
wiley   +1 more source

Effects of Deltamethrin and Endosulfan on the Hepatic Markers and Neurobehavioural Alterations in Japanese Quail (Coturnix japonica)

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Japanese quail were exposed to combined low or high doses of deltamethrin and endosulfan by daily oral gavage for 3 weeks. Co‐exposure produced dose‐dependent hepatotoxicity and metabolic disruption, with elevated AST (aspartate aminotransferase), ALP (alkaline phosphatase), LDL, VLDL and cholesterol alongside reduced body and kidney weights.
Saba Malik, Shoaib Ahmad, Muhammad Naeem, Iqra Bibi, Muhammad Sakandar Majid, Hafiza Sadia, Sheeba Riaz, Md Abu Bakkar Siddik   +7 more
wiley   +1 more source

Benzodiazepine Use and Mortality Risk: A Nationwide Cohort Study on New Benzodiazepine Users With a 5‐Year Follow‐Up

Acta Psychiatrica Scandinavica, Volume 154, Issue 5, Page 342-351, November 2026.
ABSTRACT Introduction We aimed to investigate the risks of all‐cause and cause‐specific mortality associated with dose‐dependent benzodiazepine and Z‐drug (BZDR) use in the Finnish population initiating new BZDR use with five‐year follow‐up. Methods Study subjects were included if BZDR use had started in 2006 with no BZDR dispensing during the ...
Hanna Särkilä, Heidi Taipale, Antti Tanskanen, Tero Taiminen, Reijo Sund, Terhi Kurko, Jarmo Hietala, Solja Niemelä   +7 more
wiley   +1 more source

Consent for anaesthesia: guidelines from the Association of Anaesthetists

Anaesthesia, Volume 81, Issue 11, Page 1549-1568, November 2026.
Summary Introduction Guidelines on consent for anaesthesia were first issued by the Association of Anaesthetists in 1999 and last revised in 2017. These new guidelines respond to the changing ethical, legal and clinical landscape in which anaesthetists practice. Since 2017, the Montgomery judgment has changed medical consent practice.
Andrew McLeod, David Bogod, James Brooks, Michael Devlin, Natalie Joseph‐Williams, Rehana Iqbal, Nadine Montgomery‐Allam, Felicity Plaat, Alex Ruck Keene, Cliff Shelton, Vinnie Sodhi, Michael Swart, Emma Wain, Hugo Wellesley, Jenny Westaway   +14 more
wiley   +1 more source

Investigating Potential Adverse Drug Reactions of Lisdexamfetamine Using Sequence Symmetry Analysis

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT The prevalence of ADHD is increasing rapidly, and lisdexamfetamine is increasingly popular, but few studies investigate its safety. We performed a sequence symmetry analysis (SSA) using Danish register data to identify potential ADRs associated with lisdexamfetamine in 2013–2023.
Thomas Leth Jensen, Sanne Møller Thysen, Espen Jimenez‐Solem, Anders Jørgensen, Camilla Bjørn Jensen, Hans Kristian Råket, Merete Osler, Mads Nielsen, Lars Christian Lund   +8 more
wiley   +1 more source

The Sleepless Watch: Perceived Sleep Quality of Nurses Working in High‐Intensity Settings

Nursing in Critical Care, Volume 31, Issue 6, November 2026.
ABSTRACT Background Poor sleep quality is a global health concern among nurses, particularly in high‐intensity settings. Unpredictable workloads, extended shifts and high patient acuity compromise sleep quality, negatively affecting nurses' well‐being and patient outcomes.
Ngilozi Ngenzeni Shabangu, Ntombifikile Klaas, Nomonde Goodness Makhudu, Digapeng Catherine Maditjane, Siyabonga Buthelezi   +4 more
wiley   +1 more source

Deteriorating Mental Well‐Being of the Young in the UK

Scottish Journal of Political Economy, Volume 73, Issue 5, November 2026.
ABSTRACT Using several data sets for the UK we track rising perceptions of mental well‐being among the working‐age population in the UK. The trend is apparent among all age groups and for men and women, but it is most pronounced among the young, and especially young women aged under 25.
David G. Blanchflower, Alex Bryson, David N. F. Bell   +2 more
wiley   +1 more source