Results 141 to 150 of about 92,574 (297)

Pd‐Catalyzed Asymmetric Dearomative Heck/Tsuji‐Trost Difunctionalization of Naphthalenes

open access: yesAdvanced Science, EarlyView.
We have developed a palladium‐catalyzed asymmetric dearomative Heck/Tsuji‐Trost 1,4‐difunctionalization reaction of naphthalenes, affording 4‐aminospirocyclohexene oxindole products bearing two remote chiral centers. Through the effect of the newly designed chiral sulfinamide phosphine ligand with large steric hindrance, side reactions are inhibited ...
Long‐Ling Ma   +3 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

open access: yesAdvanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang   +19 more
wiley   +1 more source

Lead and Mortality [PDF]

open access: yes
This paper examines the effect of water-borne lead exposure on infant mortality in American cities over the period 1900-1920. Infants are highly sensitive to lead, and more broadly are a marker for current environmental conditions. The effects of lead on
Michael R. Haines   +2 more
core  

Lead line (Hartford, Conn.); Other title: Leadline [PDF]

open access: yes, 2011
Semiannual; Issues from Feb. 2003- also called v. 1, no.

core  

Examining lead blood levels among Ilam\'s general population in 1402 [PDF]

open access: yesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām
Introduction:  Research on blood lead levels is crucial to reduce its societal burden and assess its health effects, as lead significantly impacts cognitive function and public health.
Shahin Shahbazi   +2 more
doaj  

Charting the Future of Stereoselective Carbohydrate Synthesis: The Essential Role of Cross‐Disciplinary Innovation

open access: yesAdvanced Science, EarlyView.
Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley   +1 more source

National Lead Poisoning Prevention Week : October 19-25, 2014 [PDF]

open access: yes
Lead free kids for a healthy future.Get your home tested.Get your child tested.National Lead Poisoning Prevention Week flyer, 18 x ...

core  

Public health implications of lead poisoning in backyard chickens and cattle: four cases [PDF]

open access: yes, 2013
Amber Roegner,1 Federico Giannitti,2 Leslie W Woods,2 Asli Mete,2 Birgit Puschner1,2 1Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA; 2California Animal Health and Food Safety Laboratory ...
Mete A   +4 more
core  

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