Results 91 to 100 of about 3,177,823 (315)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Influenza vaccines: mTOR inhibition surprisingly leads to protection
Nature Immunology, 2013 Mice immunized with influenza virus in the presence of rapamycin, which blocks the formation of germinal centers, make mostly IgM antibodies that protect against infection with multiple subtypes of influenza virus, including avian viruses.
Mcmichael, A, Haynes, B
openaire +1 more source
Irregular behaviour in stating preferences for nature protection. A Choice Experiment in Belarus [PDF]
Using choice experiment, this paper investigates how Belarusian citizens value planned Zvanets mire protection programmes. Two approaches are used to analyze ignored attributes: a debriefing question, and estimating parameters at the individual level. We
Marek Giergiczny +3 more
core
Indirect tests of the Randall-Sundrum model
, 2011 I present phenomenological implications of the Randall-Sundrum model for indirect searches, specifically a selection of flavor observables and Higgs-related collider searches.
Aaltonen T [The CDF Collaboration] +10 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Литьë и металлургия, 2013 Urgency of use of secondary lead materials and creation of appropriate technologies for production of lead parts and sheets for devices and means of radiation protection is briefly grounded.
V. A. Pumpur +2 more
doaj
Institutional causes of output volatility [PDF]
The authors investigate the relationship between the quality of institutions and output volatility. Using instrumental variable regressions, they address whether higher entry barriers and lower property rights protection lead to higher volatility.
Levon Barseghyan, Riccardo DiCecio
core
Climate Change in the Supreme Court [PDF]
, 2008 In Massachusetts v. Environmental Protection Agency, the Supreme Court confronted the issue of climate change for the first time. The Court held that the Clean Air Act gives the Environmental Protection Agency the authority to regulate greenhouse gases ...
Heinzerling, Lisa
core +1 more source
Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria [PDF]
, 2015 BACKGROUND Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria.
Bijker, Else M +5 more
core +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source