Results 131 to 140 of about 3,177,823 (315)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Editorial

CHIMIA, 2023
Claudio Battilocchio
doaj  

Revisiting Antitrust Limits to Probabilistic Patent Disputes: Strategic Entry and Asymmetric Information [PDF]

, 2010
We consider separately strategic entry and asymmetric information in the design of the settlement policy governing patent disputes, with a focus on Shapiro (2003)’s consumer protection rule.
Chiou, Jing-Yuan, Schmidtke, Richard
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evaluation of novel radiation protection devices during radiologically guided interventions

CVIR Endovascular
Background In radiologically guided interventions, medical practitioners are subjected to radiation exposure, which may lead to radiation-induced diseases. In this study, novel radiation shields for the head and neck were evaluated for their potential to
Maria E.V. Larsson, Pernilla I. Jonasson, Petra S. Apell, Peter P. Kearney, Charlotta J. Lundh   +4 more
doaj   +1 more source

Lead Debate: Protecting America’s Children [PDF]

Health Affairs, 2013
openaire   +1 more source

Cathodic corrosion and protection of lead

, 1955
info:eu-repo/semantics ...
Van Muylder, Jean, Pourbaix, Marcel
openaire   +1 more source

Dissolved Oxygen Monitoring in Kings River and Leatherwood Creek [PDF]

, 2016
The Clean Water Act (CWA) establishes the basic structure used to regulate water quality. Under the CWA, States are required to assess water bodies relative to water‐quality standards and designated beneficial uses and then to ...
Cummings, Eric, Haggard, Brian E., Matlock, Marty, Scott, Erin E.   +3 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Why charging patients in the UK for going to hospital is wrong and bad for child health

BMJ Paediatrics Open, 2022
Jonathan Broad, Sarah Boutros, Bryony Hopkinshaw, Alison Steele, Catarina Alves Soares, Olivia Lam   +5 more
doaj   +1 more source