Results 141 to 150 of about 207,226 (246)

Author Correction: Oxygenating respiratoid biosystem for therapeutic cell transplantation

Nature Communications
Seonmi Jang, Chaerim Yoo, Hyung Shik Kim, Jiyun Kim, Dong Yun Lee   +4 more
doaj   +1 more source

<i><b>Streptococcus dentisani</b></i> <b>7746 encodes a cocktail of 14 bacteriocins associated with Com and Blp-like quorum sensing regulatory systems</b>. [PDF]

J Oral Microbiol
Revilla-Guarinos A, Camelo Castillo A, Cebrián R, Ferrer MD, López-López A, Adrados-Planell A, Lahoz Oliva S, Ledesma L, Hols P, Mira Á.   +9 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Deep learning-based investigation of chloroplast translation regulatory sequences. [PDF]

Front Plant Sci
Abbasi-Vineh MA, Ingvarsson PK, Farrokhi N.   +2 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Letter to the Editor: Effective treatment of disseminated granuloma annulare with upadacitinib

JAAD Case Reports
Jiayue Zheng, MD, Sonia Sharma, MD, Kendra Wassell, RPN, Rosilene Lanzini, MD, PhD, Hermenio Lima, MD, PhD   +4 more
doaj   +1 more source

A missed opportunity: faith leaders and the HPV vaccination effort in Addis Ababa, Ethiopia. [PDF]

Glob Health Action
Berhanu W, Yigremachew S, Hanson C, Avermark H, Addissie A, Herzig van Wees S.   +5 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Ten simple rules for coordinating a large digital health project: Perspectives from EU and implications for global contexts. [PDF]

PLoS Comput Biol
Sacchi L, Zupan B, Quaglini S.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source