Results 111 to 120 of about 5,869,436 (291)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Leader Firms in the Dutch Maritime Cluster [PDF]

open access: yes
The cluster-concept is often-used to analyse a country's key industries. The maritime industry is one of the most well-defined clusters in the Netherlands.
Peter W. De Langen, Michiel Nijdam
core  

The Role and Impact of Supplemental Instruction in Accelerated Developmental Math Courses

open access: yesJournal of College Academic Support Programs, 2018
DOI: https://doi.org/10.36896/1.1fa2 A difficult issue for tutoring programs is low participation, especially at commuter campuses. At the University of Houston-Downtown, this problem seems particularly acute for developmental education (DE) courses ...
Tanu K. Altomare   +1 more
doaj  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Principles of Local Development and the European Leader Programme Applied to Fishing Areas: What are the Specific Features? Comparative Approach of Two Lags in France

open access: yesEuropean Countryside
The article focuses on the implementation of the European LEADER program in the specific context of fishing areas. Complementing the European Common Fisheries Policy, whose sectoral objective is to preserve fishery resources while ensuring economic ...
Chevalier Pascal   +1 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

A LEADER program hozzájárulása az AKG prioritásaihoz

open access: yes, 2011
Dolgozatom első fejezetében röviden bemutatom A Közös Agrárpolitika rendszerét (KAP) és a legfontosabb reformokat. A KAP keretein belül jelentős támogatások kerülnek kiosztásra minden évben, melyek az Unió kiadásainak körülbelül 40 %- át teszik ki ...
Bunkóczi, Judit Lili
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

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