Results 41 to 50 of about 552,831 (291)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Testing performance of an interest rate commission agent banking system (AIRCABS) [PDF]
Banks and Bank Systems, 2017 This paper sought to analyze data and interpret statistical results in testing the performance of an interest rate commission agent banking system.
Ameha Tefera Tessema, Jan Walters Kruger
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Conceptualising Responsible Leadership in South Africa: An Interactive Qualitative Analysis
South African Journal of Business ManagementPurpose: The studying of responsible leadership as a leadership construct is facing challenges in defining, specifically within a South African context. This has been amplified by real-world challenges such as the increased unethical behaviour.
Anton Grobler, Werner Koen
doaj +1 more source
The Future of Blockchain Technology and its Application and Challenges with Regard to International Migration within the African Union [PDF]
Ovidius University Annals: Economic Sciences Series, 2023 This paper explores the potential application and challenges of blockchain technology in addressing the complex issues surrounding international migration within the African Union (AU).
Charles Chatta +2 more
doaj
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Unit Costing of Health Extension Worker Activities in Ethiopia: A Model for Managers at the District and Health Facility Level [PDF]
International Journal of Health Policy and Management, 2018 Background Over the last decade, Ethiopia has made impressive national improvements in health outcomes, including reductions in maternal, neonatal, infant, and child mortality attributed in large part to their Health Extension Program (HEP).
Maureen E. Canavan +4 more
doaj +1 more source
A Framework for Knowledge Management System Adoption in Small and Medium Enterprises
Computers, 2022 Knowledge is a key competitive advantage for small and medium enterprises (SMEs) as a way of competing with other organisations. There is a need to investigate SME adoption of knowledge management systems (KMSs).
Werner Richardt van Zyl +2 more
doaj +1 more source
Philosophy, Ethics, and Humanities in Medicine, 2011 The ethical foundation of the medical profession, which values service above reward and holds the doctor-patient relationship as inviolable, continues to be challenged by the commercialization of health care. This article contends that a realigned leadership framework - one that distinguishes being a leader as the ontological basis for what leaders ...
openaire +4 more sources