Results 191 to 200 of about 199,980 (258)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The impact of artificial intelligence application on employees' job insecurity: the moderating roles of self-efficacy and transformational leadership. [PDF]

Front Psychol
Fu W, Zhang H.
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Educational Background and Demographic Characteristics of Anesthesiology Department Chairs in the United States. [PDF]

Anesthesiol Open
Estright AW, Pruitt KA, Pope SE, Childers M, Clark SC, Singh M, Alter JA, Hill HE, Tollinche LE.   +8 more
europepmc   +1 more source

How leadership emotional intelligence promotes team innovation: parallel mediating roles of psychological safety and knowledge sharing. [PDF]

Front Psychol
Xing S, Yu X, Yu J, Chen J.
europepmc   +1 more source

The Leadership Perception Gap in Spanish Anesthesiology Departments: A National Cross-Sectional Survey Comparing Department Heads and Staff Views. [PDF]

J Healthc Leadersh
Poves-Álvarez R, Gómez-Sánchez E, Martínez-Rafael B, Lorenzo-López M, Rodríguez-Cerón G, Gómez-Pesquera E, López-Herrero R, Arranz-Molinero E, Vaquerizo-Villar F, Hornero R, Gavilan D, Tamayo E.   +11 more
europepmc   +1 more source

From inclusive leadership to thriving at work: the mediating and moderating roles of teaching efficacy and professional identity. [PDF]

Front Psychol
Gao Q, Li Y, Zhang G, Wang B, Dzhumabaeva M, Adylbek Kyzy G.   +5 more
europepmc   +1 more source