Results 141 to 150 of about 866,146 (296)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Chief Justice Leadership: A Brief Sketch of Its Landscape, Structure, and Operation [PDF]

open access: yes, 2019
This article examines chief justice leadership of the United States Supreme Court during the judicial decision-making process and develops a model of such leadership in three distinct parts: landscape, structure, and operation.
Root, David A.
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Hubungan Gaya Kepemimpinan Mandor Panen dan Motivasi Kerja Pemanen dengan Kinerja Pemanen di PT Perkebunan Nusantara VII Unit Kebun Kelapa Sawit (Ukks) Rejosari Natar, Lampung Selatan [PDF]

open access: yes, 2016
This research aims to know the harvest foreman leadership style, motivation and performance level of harvesters, relation between harvest foreman leadership style and performance of harvester, relation between work motivation of harvesters and ...
Alimah, F. C. (Faridatu)   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The association of perceived leadership style and subjective well-being of employees in a tertiary hospital in Germany. [PDF]

open access: yesPLoS One, 2022
Erschens R   +12 more
europepmc   +1 more source

Tri Rismaharini's Androgynous Leadership: Strategizing “Hegemonic Masculinity”i [PDF]

open access: yes, 2016
This paper analyses the leadership style of Tri Rismaharini, the Mayor of Surabaya City (2010-2020) using feminist research methodology by centralizing on women‟s personal experiences in a specific context to gain knowledge based on their real life ...
Dewi, K. H. (Kurniawati)
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

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