Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Analisa Pengaruh Leadership Style terhadap Organization Performance melalui Learning Organization dan Employee Satisfaction (Studi Kasus pada Akuntan Publik di Kantor Akuntan Publik di Surabaya) [PDF]
, 2015 This study aimsed to know the direct and significant influence of leadership style to organizational performance through learning organization and employee's satisfaction in the public accounting firm in Surabaya.
Nathania, S. Y. (Stephanie)
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The role of the nursing coordinator and the leadership style in the Italian healthcare organizations. [PDF]
Acta Biomed, 2023 Lupo R +10 more
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The Effect of Leadership Style on Midwives' Performance, Southwest, Ethiopia. [PDF]
J Healthc Leadersh, 2023 Fenta Kebede B +4 more
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
DIMENSI-DIMENSI GAYA KEPEMIMPINAN BASS DAN AVOLIO MENURUT PERSEPSI KARYAWAN DALAM MEMBANGUN GAYA KEPEMIMPINAN YANG EFEKTIF (Studi Pada Bank BRI Cabang Wates) [PDF]
, 2012 This study aims to determine the perceptions of employees about leadership dimensions contained in the leadership model of Bass and Avolio and know the style of leadership they deem effective for a leader. This study used a qualitative method where data
ANDRIYANI , Andriyani, APRILITA, Bina
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The Impact of Transformational Leadership Style on Nurses' Job Satisfaction: An Integrative Review. [PDF]
SAGE Open Nurs, 2023 Gebreheat G, Teame H, Costa EI.
europepmc +1 more source