Results 91 to 100 of about 429,703 (293)

Leading-Edge Roughness Affecting Diamond-Wing Aerodynamic Characteristics

Aerospace, 2018
Diamond wing configurations for low signature vehicles have been studied in recent years. Yet, despite numerous research on highly swept, sharp edged wings, little research on aerodynamics of semi-slender wings with blunt leading-edges exists. This paper
Andrei Buzica, Lisa Debschütz, Florian Knoth, Christian Breitsamter   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Experimental quantification of unsteady leading-edge flow separation

We propose here a method to experimentally quantify unsteady leading-edge flow separation on aerofoils with finite thickness. The methodology relies on the computation of a leading-edge suction parameter based on measured values of the partial ...
Deparday, Julien, Eldredge, Jeff D., He, Xiaowei, Mulleners, Karen, Williams, David R.   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On the effects of leading edge vortex generators on an OA209 airfoil

, 2009
Leading edge vortex generators have been found to significantly increase the aerodynamic performance of an airfoil under dynamic stall conditions. However, the principle of operation of these devices is still unclear.
Gardner, Anthony, Heine, Benjamin, Mulleners, Karen, Mai, Holger   +3 more
core  

The Analysis of Leading Edge Deformations on Turbomachine Blades

Energies, 2019
With recent advancements in the development of material and manufacturing technology, the leading edge geometry of turbomachine blades has attracted widespread attention.
Le Li, Huoxing Liu
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

High-order computations on aerofoil-gust interaction noise and the effects of wavy leading edges

, 2012
High-order accurate numerical simulations are performed to investigate the effects of wavy leading edges on aerofoil gust interaction (AGI) noise. The present study is based on periodic velocity dis-turbances predominantly in streamwise (x-) and vertical
Lau, Alex Siu Hong
core