Results 101 to 110 of about 429,703 (293)

Leading edge aerothermal inverse design of hyersonic vehicle based on homotopy optimization method

, 2011
Blunt leading edge with profiles of circular or power law shape is often used to decrease the aerodynamic heating of a vehicle when it flights into hypersonic regime.
Hu SC(胡守超), Cui, K (reprint author), Chinese Acad Sci, Inst Mech, LHD, Beijing 100190, Peoples R China., Yang GW(杨国伟), Wang XP(王秀平), Gao TY(高太元), Cui K(崔凯)   +5 more
core   +1 more source

Leading-edge vortices in insect flight

, 2010
INSECTS cannot fly, according to the conventional laws of aerodynamics: during flapping flight, their wings produce more lift than during steady motion at the same velocities and angles of attack1?5.
Charles P. Ellington (17226214), Coen Van Den Berg (17226217), Sandy Willmott (17170156), Adrian L. R. Thomas (17226289)   +3 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A fence barrier method of leading edge cell capture for explorative biochemical research [PDF]

, 2017
The scratch or wound-healing assay is used ubiquitously for investigating re-epithelialisation and has already revealed the importance of cells comprising the leading edge of healing epithelial wounds.
Thompson, EW, Leavesley, DI, Thompson, Erik W., Murray, RZ, Erik W. Thompson, Wager, LJ, Lucas J. Wager, David I. Leavesley, Wager, Lucas J., Leavesley, David, Murray, Rachael Z., Rachael Z. Murray   +11 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Flow Field Measurements to Characterize Flap Side-Edge Noise Generation

, 2013
n this paper, the relation between noise generated at flap side-edges (FSE) and mean flow characteristics in the vicinity of the FSE solid surface is investigated.
Karl-Stephane S. Rossignol, Rossignol, Karl-Stephane   +1 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Shape design to minimize the peak heat-flux of blunt leading-edge

, 2013
To minimize the peak heat-flux of hypersonic blunt leading-edge, the Mini-Max optimization model is introduced for the first time for aerothermodynamics optimization.
Hu SC(胡守超), 崔凯, Cui K(崔凯)
core   +1 more source

Astrocyte glucose metabolism highlights the link between cannabis use and social behavior

Journal of Diabetes Investigation, 2022
Dipanjan Chanda, In‐Kyu Lee
doaj   +1 more source