Results 121 to 130 of about 429,703 (293)

Examination of three candidate technologies for high-lift devices on an aircraft wing [PDF]

, 2005
A research programme was initiated to examine three candidate high-lift technologies, which would, if implemented, simplify the mechanical complexity of the multiple component trailing-edge devices traditionally employed on civil transport aircraft ...
Knepper, Angela Marie
core  

Leading-Edge Technologies [PDF]

IT Professional, 2019
Rick Kuhn, Samee U. Khan
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Impact of central versus side jet impingement configurations on the cooling of a gas turbine leading edge at varying reynolds numbers and rotational speeds: experimental investigations

International Journal of Thermofluids
This experimental study investigated the cooling performance of two jet impingement configurations central and side. The effects of Reynolds numbers ranging from 5000 to 11,000 and rotation speeds ranging from 0 to 200 rpm on the total heat transfer ...
Ahmad Alqasrawi, Emad Elnajjar, Amin Safi, Mohammad O. Hamdan, Salah A.B. Al Omari   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Theoretical modeling of leading edge vortices using the leading edge suction parameter

, 2012
A theoretical low-order model to predict the forces and flow evolution on airfoils and flat plates undergoing arbitrary 2D unsteady maneuvers is presented.
Granlund, Kenneth, Ol, Michael V., Kiran Kumar Ramesh, Ashok Gopalarathnam, Gopalarathnam, Ashok, Edwards, Jack R., Jack Edwards, Ramesh, Kiran, Kenneth Granlund, Michael Ol   +9 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Recycling endosome membrane incorporation into the leading edge regulates lamellipodia formation and macrophage migration

, 2010
In comparison to our knowledge of the recycling of adhesion receptors and actin assembly, exactly how the cell controls its surface membrane to form a lamellipodium during migration is poorly understood.
Murray, Rachael, Kelly J. Veale, Ruby P. Estrella, Whittaker, Shane P., Murray, Rachael Z., Veale, Kelly, Veale, Kelly J., Carolin Offenhäuser, Estrella, Ruby P., Shane P. Whittaker, Offenhäuser, Carolin, Whittaker, Shane, Estrella, Ruby, Rachael Z. Murray   +13 more
core   +1 more source