Results 131 to 140 of about 429,703 (293)
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
, 2004 Both the Arp2/3 complex and cofilin are believed to be important for the generation of protrusive force at the leading edge; however, their relative contributions have not been explored in vivo.
Macaluso, F. +3 more
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Aerothermal optimization of hypersonic vehicle leading edge based on genetic algorithm
, 2012 This work is concerned with the design of a leading edge for hypersonic vehicles used to minimize the peak heat flux of the leading edge.The leading edge is parameterized by using B-spline curve method.The hypersonic flow field and the heat flux ...
崔凯 +4 more
core
Abraham Lincoln No. 1 in a Series of Great Word Processors
, 2023 This poster features a portrait of Abraham Lincoln. This poster also features a partial text of Gettysburg Address.https://scholarsjunction.msstate.edu/fvw-posters/1040/thumbnail ...
Leading Edge
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Design Optimization and Testing of Seamless Morphing Leading Edge for Large Civil Aircraft
Engineering ProceedingsClimate change has prompted the aviation industry to decrease its emissions of greenhouse gases. With their aerodynamic shape adaptability, morphing leading edges have great potential in the application of laminar flow wings and are beneficial to green ...
Zhigang Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source