Results 171 to 180 of about 429,703 (293)

Rare Subscapularis Anterior Leading Edge Tear following Traumatic Posterior Shoulder Dislocation: A Case Report. [PDF]

J Orthop Case Rep
Sancilio C, Pulido J, Mousad A, Sorkin S, Mastroianni M, McCormick F.   +5 more
europepmc   +1 more source

Analogies between the periphery of cancer and the leading edge of pulmonary fibrosis. [PDF]

J Transl Med, 2023
Pernia Marin M, Salvatore M.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The Sharp Leading Edge of SHEFEX II

, 2008
SHEFEXII is a faceted re-entry body with a sharp leading edge. This paper presents the design, the according aero-thermodynamic loads and the thermo-mechanical analyses of the leading edge of ...
Weihs, Hendrik, Böhrk, Hannah, Laux, Torsten   +2 more
core  

Novel GABAAR antagonists target networked gene hubs at the leading edge in high-grade gliomas. [PDF]

Neuro Oncol
Shard C, Jones AC, Fouladzadeh A, Palethorpe HM, Francis A, Boyle Y, Ormsby RJ, Dewdney B, Yeow Y, Mahajan I, Barker M, Kuznetsova I, Jones ME, Patil A, Rezaeiravesh S, Ying Ng Z, Poonnoose SI, Bosco A, Valvi S, Forrest ARR, Johns TG, Gomez GA, Fletcher EV.   +22 more
europepmc   +1 more source

Flow development and leading edge vorticity in bristled insect wings. [PDF]

J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2023
O'Callaghan F, Lehmann FO.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Leadless Pacemakers: The "Leading Edge" of Quality of Life in Cardic Electrophysiology. [PDF]

Curr Cardiol Rep
Sears SF, Jordan EW, Hashmath Z, Sargeant MM, Catanzaro J, Nekkanti R, Shantha G.   +6 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source