Results 181 to 190 of about 429,703 (293)

The kinesin KIF3AC recycles endocytosed integrin to polarize new adhesion formation toward the leading edge. [PDF]

Proc Natl Acad Sci U S A
Rockenbach JAZ, Nader GPF, Antoku S, Gundersen GG.   +3 more
europepmc   +1 more source

Nurse practitioners on 'the leading edge' of medication abortion care: A feminist qualitative approach. [PDF]

J Adv Nurs, 2023
Carson A, Cameron ES, Paynter M, Norman WV, Munro S, Martin-Misener R.   +5 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Wide-Field Optical Redox Imaging with Leading-Edge Detection Enables Assessment of Treatment Response and Heterogeneity in Patient-Derived Cancer Organoids. [PDF]

Cancer Res
Gillette A, Udgata S, Schmitz AE, Stoecker JN, Kratz JD, Deming DA, Skala MC.   +6 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Cholesterol and Sphingomyelin Polarize at the Leading Edge of Migrating Myoblasts and Involve Their Clustering in Submicrometric Domains. [PDF]

Biomolecules, 2023
Vanderroost J, Avalosse N, Mohammed D, Hoffmann D, Henriet P, Pierreux CE, Alsteens D, Tyteca D.   +7 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Glioblastoma exploits ATP from leading-edge astrocytes to fuel its infiltrative growth revealed by spatially resolved chimeric analysis. [PDF]

Sci Adv
Yang G, Niu X, Gan J, Yu T, Li M, Xiao P, Zhang R, He P, Yang Y, Cui Y, Huang X, Wang Y, Mao Q, Zhou R.   +13 more
europepmc   +1 more source

Leading Edge: Intratumor Delivery of Monoclonal Antibodies for the Treatment of Solid Tumors. [PDF]

Int J Mol Sci, 2023
Blanco E, Chocarro L, Fernández-Rubio L, Bocanegra A, Arasanz H, Echaide M, Garnica M, Piñeiro-Hermida S, Kochan G, Escors D.   +9 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source