Results 61 to 70 of about 429,703 (293)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Leading Edge, 2017 Signals are letters to the editor submitted by readers of The Leading Edge.
P. Anderson, A. Vesnaver
openaire +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Analysis of composite wing structures with a morphing leading edge [PDF]
, 2011 One of the main challenges for the civil aviation industry is the reduction of its environmental impact. Over the past years, improvements in performance efficiency have been achieved by simplifying the design of the structural components and using ...
Morishima, Ryoko
core
Aerospace, 2016 This paper discusses wind tunnel test results aimed at advancing active flow control technology to increase the aerodynamic efficiency of an aircraft during take-off.
Matthias Bauer +3 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Airfoil noise reductions through leading edge serrations
This paper provides an experimental investigation into the use of leading edge (LE) serrations as a means of reducing the broadband noise generated due to the interaction between the aerofoil’s LE and impinging turbulence.
Joseph, P.F. +5 more
core +1 more source
Effects of Leading Edge Protuberances on the Aerodynamic Performance of 2D Cambered Airfoil
, 2012 The pressure and lift coefficients were measured for airfoils with leading edge protuberances in a subsonic wind tunnel and compared with the performance of a baseline NACA 4415 airfoil with a straight leading edge.
Humera Golandaz +2 more
core +1 more source
Application of digital particle image velocimetry to insect aerodynamics: measurement of the leading-edge vortex and near wake of a Hawkmoth [PDF]
, 2007 Some insects use leading-edge vortices to generate high lift forces, as has been inferred from qualitative smoke visualisations of the flow around their wings.
Taylor, Graham K. +3 more
core +1 more source