Results 31 to 40 of about 126,363 (263)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analysis on Leakage Inductance and Winding Resistance of High Frequency Toroidal Transformer with Interleaved Winding and Litz Wire

Jurnal EECCIS (Electrics, Electronics, Communications, Controls, Informatics, Systems)
High-frequency transformers offered numerous advantages but also presented several challenges. As frequency increased, the dimensions of the transformer decreased, making parasitic parameters more dominant and unavoidable.
Dody Yunus Putra Siregar, Wijono, Muhammad Aziz Muslim   +2 more
doaj   +1 more source

Influence of Pipeline Insulation Leakage Points on the Distribution of Geomagnetically Induced Current and Pipe-Soil Potential

IEEE Access, 2019
During geomagnetic storms, geomagnetically induced currents (GIC) and pipe-soil potential (PSP) generated in a pipeline present a risk to the safe operation of the pipeline.
Chenglian Ma, Chunming Liu
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Analysis of Leakage Current and Insulator Resistivity for Quality Assurance of Medium Voltage Network Polymer Insulators Alumina - SiO2 in Tropical Climate Simulator Room

Teknik, 2021
The tropical climate of Indonesia, which has moderately high rainfall, has an impact on the output of outdoor insulators. The presence of chemical particles, pollen, and salt in the air will bind to the insulating material's outer surface and settle ...
Agnes Manik Sari Utami, Abdul Syakur, Hermawan Hermawan   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Experimental and Numerical Investigations on the Local Direct Leakage Process of Rotary Regenerative Air Preheater

Applied Sciences, 2020
An inherent defect of the operating rotary air preheaters (RAPH) is known as leakage, which seriously hinders the efficient and safe operation of RAPH.
Hua Zhu, Dechao Li, Henglin Pu, Limin Wang, Yang He, Yufan Bu, Defu Che   +6 more
doaj   +1 more source

POLKA: Towards Leakage-Resistant Post-quantum CCA-Secure Public Key Encryption

, 2023
As for any cryptographic algorithm, the deployment of post-quantum CCA-secure public key encryption schemes may come with the need to be protected against side-channel attacks. For existing post-quantum schemes that have not been developed with leakage in mind, recent results showed that the cost of these protections can make their implementations more
Hoffmann, Clément, Libert, Benoît, Momin, Charles, Peters, Thomas, Standaert, François-Xavier, Public-Key Cryptography - PKC 2023 - 26th IACR International Conference on Practice and Theory of Public-Key Cryptography   +5 more
openaire   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source