Results 61 to 70 of about 540,883 (315)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Laboratory Investigation of the Leakage Characteristics of Unburied HDPE Pipes
, 2015 In this research work, the leakage characteristics of the viscoelastic material HDPE is investigated and compared to other materials like uPVC which is elastic and galvanised steel which is rigid in nature. Under no axial loading, the deformation in HDPE
King, R.T.F. Ah +6 more
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Archives of Clinical and Experimental Surgery, 2014 Background: Anastomotic leakage remains a major complication following colorectal surgery, with a largely unknown pathophysiology and limited treatment options.
Tyge Nordentoft, Kathrine Holte
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Quantitative and Qualitative Analysis of Dynamic Cavernosographies in Erectile Dysfunction due to Venous Leakage [PDF]
, 1989 Of 521 patients with erectile dysfunction in whom a multidisciplinary approach was used, 145 (27.8%) showed venous leakage as (concomitant) etiology of the impotence in dynamic cavernosography.
Stief, Christian Georg +1 more
core +1 more source
You-qi chuyunObjective Transient processes like leakage and commissioning in CO2 pipeline operation pose simulation challenges due to the unique physical properties and phase behavior of CO2.
Xinyuan MA +6 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Research on leakage hazards of embankments based on 3D electrical resistivity tomography technology
GrađevinarLeakage is a common issue in reservoirs; however, accurately detecting its location and seepage diameter can be challenging owing to complex geological conditions.
Yuehang Zhao +4 more
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source